European-American4 participants with genotypic and interview data were obtained from the Study of Addiction: Genetics and Environment (SAGE; Bierut et al., 2010). SAGE was funded as part of the Gene Environment Association Studies (GENEVA) initiative supported by the National Human Genome Research Institute (dbGaP study accession phs000092.v1.p1). For this study, alcohol dependent and control participants were recruited from three large, complementary datasets ascertained for alcohol (Collaborative Study of the Genetics of Alcoholism; COGA; Foroud et al., 2000; T. Reich et al., 1998), nicotine (Collaborative Study of the Genetics of Nicotine Dependence; COGEND; Bierut et al., 2007) and cocaine (Family Study of Cocaine Dependence; FSCD; Bierut, Strickland, Thompson, Afful, & Cottler, 2008) dependence. Childhood abuse data were only collected in FSCD and from a subset of COGA participants, constraining our analyses to 859 participants (Table 3). Genotyping details are available in the Supplement. The top SNP from CATS, rs604300 in MGLL (call rate = 100%, HWE p = 0.60, MAF = 0.11), was the only variant examined for the purposes of replication within SAGE and was coded as major allele homozygotes
