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Chunk #26 — Methods — Study of Addiction: Genetics and Environment (SAGE; N = 859)

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Monoacylglycerol lipase (MGLL) polymorphism rs604300 interacts with childhood adversity to predict cannabis dependence symptoms and amygdala habituation: Evidence from an endocannabinoid system-level analysis.
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the Supplement. The top SNP from CATS, rs604300 in MGLL (call rate = 100%, HWE p = 0.60, MAF = 0.11), was the only variant examined for the purposes of replication within SAGE and was coded as major allele homozygotes (GG) and A allele carriers (AA/AG) due to the rareness of A allele homozygosity (n = 8). The Institutional Review Board at each contributing institution reviewed and approved the protocols for genetic studies under which all participants were recruited.