the Supplement. The top SNP from CATS, rs604300 in MGLL (call rate = 100%, HWE p = 0.60, MAF = 0.11), was the only variant examined for the purposes of replication within SAGE and was coded as major allele homozygotes (GG) and A allele carriers (AA/AG) due to the rareness of A allele homozygosity (n = 8). The Institutional Review Board at each contributing institution reviewed and approved the protocols for genetic studies under which all participants were recruited.