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Chunk #40 — Gene network inference within tissues using cross-individual expression variation

Source
Human genomics. The Genotype-Tissue Expression (GTEx) pilot analysis: multitissue gene regulation in humans.
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could be regulated by a large number of transcription factors (fig. S30A). Finally, we compared coexpression modules learned in each tissue individually to those learned in other tissues, based on common gene membership and correlation of first principal components of expression variation across individuals (fig. S30B). Many modules showed correlation between principal components to other modules across tissues but lacked common genes, demonstrating that similarity in patterns of variation is sometimes only visible at the module level.