The availability of multiple tissues per individual further allowed us to define modules of co-regulated genes within each individual, by correlating gene expression across tissues for the same individual (14). Merging modules across individuals produced 117 modules (fig. S6E), containing between 25 and 414 genes. Each of these modules corresponds to a multitissue expression pattern for a gene, enabling us to study changes in the regulatory program of genes that affect multiple tissues at a time.
