The 225 replication attempts in East Asians aimed to replicate a total of 131 SNPs associated with disease with genome-wide significance in Europeans, which results in an average of 1.75 replication attempts per associated SNP (range = 1–7). Thus, our estimates of replicability could be biased if replicated SNPs gathered more replication attempts per SNP, or more associated SNPs in European populations. During the analysis, and as noted in the text, we applied an additive filtering to ensure no bias in the estimates of replicability and correlations between European and East Asian OR. Specifically, we repeated the analysis selecting only the largest replication attempt per SNP, resulting in a filtered set of 123 attempts. The SNPs ascertained for the filtering are indicated in Table S5.
