Here, we provide a comprehensive overview of specific brain cell types implicated in a range of brain-related phenotypes using both mouse and human brain scRNA data. We show that results from brain-related GWAS data consistently map to excitatory pyramidal neurons (CA1 and SS) and inhibitory MSNs and less so to glial and embryonic cells. The largest degree of consistency across methods and tissue origins (rodent and human) was found for implication of pyramidal cells in schizophrenia and cognitive performance. In contrast, GWAS data from neurological disorders mapped to fewer cell types and also to cell types that were distinct from psychiatric and substance use disorders.
