enhancement in eCB signaling could result in increased activity of BLA pyramidal neurons, and contribute to the expression of physiological and behavioral responses to repeated stress. However, CB1 receptors also modulate excitatory transmission in the BLA (Azad et al, 2003), which could counteract the effects on GABAergic transmission. The balance between the effects of stress-induced increases in eCB signaling on GABAergic and glutamatergic transmission will determine the net influence of BLA neuron activity. Determining the effects of repeated stress on eCB regulation of excitatory transmission will be required to address this issue.
