This study shows that repeated homotypic stress exerts metaplastic control of eCB-mediated short-term signaling in the BLA and provides further insight into the synaptic adaptations in eCB signaling that occur in response to repeated stress. Further behavioral and cellular studies into these adaptations may uncover novel approaches to the treatment of stress-related neuropsychiatric disorders, and help elucidate neural mechanisms subserving the interaction between stress and mental illness.
