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Chunk #21 — RESULTS — Theoretical Analysis of MTAG’s Performance

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Multi-trait analysis of genome-wide association summary statistics using MTAG.
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The power and FDR formulas (in contrast to the fully general MSE formula) assume that the true effect sizes βj are drawn from some known mean-zero mixture of multivariate normal distributions. This class of distributions includes multivariate spike-and-slab distributions and other fat-tailed distributions that may be relevant in applications of MTAG.