To explore the suggestion that loci initially identified through GWA studies may also harbor independent susceptibility variants, perhaps rarer and of greater effect, we examined the region overlapping ZNF804A (chr2:185,171,338—185,512,459 in NCBI Build 36) for large (containing at least 10 consecutive SNPs) CNVs in 3828 schizophrenia patients, 407 bipolar disorder patients and 39 481 controls not known to have any psychiatric disorder (see Materials and methods). In addition, 1173 patients with other psychiatric disorders (945 anxiety or anxiety-related disorder patients and 662 depression cases, 434 of whom were also diagnosed with anxiety or anxiety-related disorders) were available.
