We carried out tests for association with schizophrenia and psychosis and also with the broader phenotype of combined psychiatric disorders. A schizophrenia patient harbored a deletion of the entire ZNF804A gene (Figure 1), but no ZNF804A structural variants were identified in the control set, leading to a P-value of 0.49 for association with schizophrenia. A bipolar disorder patient had a duplication of the first exon of the gene (Figure 1), resulting in a P-value of 0.013 for association with psychosis. A ZNF804A deletion was also identified in a patient with anxiety (Figure 1), leading to a P-value of 0.0016 for association with the larger set of psychiatric disorders.
