(Andreasen et al., 1996). To further classify tissue volumes into gray matter (GM), white matter (WM) and cerebrospinal fluid (CSF), we employed a discriminant analysis method of tissue segmentation based on automated training class selection that utilized data from the T1 and T2 sequences (Harris et al., 1999). In this study, we examined total and lobar (Talairach atlas-based frontal, temporal and parietal sub-divisions) GM and WM brain volumes and lateral ventricles.