We assessed genetic background-specific effects, which could be due to interactions with background-specific variation or alternatively, due to different functional variation at the locus of interest. We combined the EA and AA samples and performed logistic regression analyses with adjustment using a LAMP main effect covariate and a LAMP x SNP interaction term (Table 2). We compared the OR across different categories of admixture. We split the AA individuals into high and low admixture categories by the approximate median %CEU of 15%, and calculated the OR and 95% confidence interval within these and the EA group (see Figure 1).
