In agreement with reports from several other groups (Gorwood et al., 2001; Lee and Ryu, 2002; Wiesbeck et al., 2006), we did not find significant association after permutation between the well-studied DRD3 BaII polymorphism (rs6280) and AD. However, we did show that another SNP (rs2654754, p = 0.0021, β = 0.24) in DRD3 is associated with the quantitative trait of ISENS. Perhaps we obtained these findings when other researchers did not because our sample size is larger, we captured most of the variation in DRD3 with our 11 tSNPs, and we assessed quantitative alcohol-related traits in addition to the dichotomous phenotype. However, the chance that this is a false positive is greater in light of the fact that the MAF = 2.5%.
