Overall, we found evidence for association with modest effect sizes between a small number of DA-related genes and AD, alcohol-related traits, and disinhibitory phenotypes. The minor allele frequencies for several of the positive SNPs are low. The limited number of positive signals suggests that these 10 DA system genes play a minor role in susceptibility to AD and related disinhibitory psychopathology, which is consistent with previous meta-analyses, reviews, and reports with rigorous methodology.
