AAs. The genomic inflation factor λs were 1.017 and 1.007 for EAs and AAs, respectively. The quartile-quartile plots are shown in Figure 1C, D. Despite restricting the control subjects to trauma exposed subjects, which removed nearly one third of the sample, the GWAS results for EAs were very similar to those derived from the whole cohort (Figure S3 in Supplement 1). Single nucleotide polymorphism rs406001 on chromosome 7p12 remained the most significant SNP, followed by rs382903 and rs450378 located in the same region of chromosome 7p12 with p values ranked as the second and fourth in the results. The first intron of TLL1 remained the second most significant region. However, probably due to the reduced sample size, no SNPs reached genome-wide significance in the subsample. Genome-wide association study results in AAs also yielded no significant association regions.
