We tested the association between rs17664708 and CaD in independent AAs (758 CaD and 280 healthy controls) and EAs (568 CaD and 318 healthy controls) from our own sample. The genotype distribution of this SNP was in HWE in both cases and controls for AAs and EAs (In AAs, P=1 for both cases and controls; In EAs, P=0.17 and P=0.80 for cases and controls, respectively). We replicated the association of rs17664708 with CaD in AAs after adjusting for sex and age (OR=2.81, 95% CI=1.23–6.45, P=0.0068), but not in EAs (OR=1.04, 95% CI=0.77–1.40, P=0.82). The MAF of rs17664708 in the replication AA sample was 0.013 and 0.038 in controls and cases, respectively, which approximated the values from the SAGE AA sample.
