Considering that the strongest linkage signal on chromosome 8 was observed only in AAs, we performed a joint analysis for the association of rs17664708 to CaD in AAs including sex, age, and global or local ancestry as covariates (Table 3). To permit comparison, analysis results with adjustment for global or local ancestry in each AA sample are also listed in Table 3. The association results remained significant after adjusting for either global (P=0.00044) or local ancestry (P=0.00075), which argues against the possibility that the significant association was caused by population stratification in AAs.
