We excluded 85 of the 3112 replication samples due to an unknown PTSD diagnosis. In the remaining 3027 subjects, 1899 were EAs, including 207 PTSD cases. Of the four SNPs genotyped in the replication sample, the two located at TLL1, rs6812849 and rs7691872, were significantly associated with PTSD with p values of 6.3×10−6 and 2.3×10−4, respectively. Upon combining the GWAS and replication samples, rs6812849 reached genome-wide significance with p = 3.1×10−9, and rs7691872 reached p = 1.2×10−7. When the analyses were restricted to subjects with trauma exposure, the p values for rs6812849 and rs7691872 were 1.6×10−3 and 2.5×10−3, respectively, in the replication sample and 1.2×10−6 and 4.3×10−6, respectively, in the combined sample. The association between PTSD and the two SNPs on chromosome 7p12 was not replicated (Table 2).
