representative animal showed that the graft contained approximately 2,106 ± 313 TH-positive cells/mm3 human antigen-positive cells (donor-derived cells). This number of donor-derived dopaminergic neurons survived in the grafts was comparable with transplants with hESC-derived dopaminergic neurons [5]. We did not observe any structures resembling teratoma-like tissues by thorough histological analyses in the grafts in any animals regardless of receiving medium alone or iPSC-derive cells. Overall, these results were similar to what has been reported for hESC-derived cells transplanted in the same 6-OHDA rat PD model, indicating that iPSC-derived cells can survive in vivo and can ameliorate behavioral deficits in PD rats.
