Medical Research Council FundRef identification ID: http://dx.doi.org/10.13039/501100000265 MR/N015746/1 to P.F.O. S.W.C. is funded from the UK Medical Research Council (MR/N015746/1). This report represents independent research (part)-funded by the National Institute for Health Research (NIHR) Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King's College London. The views expressed are those of the authors and not necessarily those of the NHS, the NIHR, or the Department of Health.