PRSice-2: Polygenic Risk Score software for biobank-scale data.
paper
Cited
Public
- Authors
- Choi, Shing Wan; O'Reilly, Paul F
- Year
- 2019
- Journal
- GigaScience
- PMID
- 31307061
- DOI
- 10.1093/gigascience/giz082
- PMCID
- PMC6629542
BACKGROUND: Polygenic risk score (PRS) analyses have become an integral part of biomedical research, exploited to gain insights into shared aetiology among traits, to control for genomic profile in experimental studies, and to strengthen causal inference, among a range of applications. Substantial efforts are now devoted to biobank projects to collect large genetic and phenotypic data, providing unprecedented opportunity for genetic discovery and applications. To process the large-scale data provided by such biobank resources, highly efficient and scalable methods and software are required. RESULTS: Here we introduce PRSice-2, an efficient and scalable software program for automating and simplifying PRS analyses on large-scale data. PRSice-2 handles both genotyped and imputed data, provides empirical association P-values free from inflation due to overfitting, supports different inheritance models, and can evaluate multiple continuous and binary target traits simultaneously. We demonstrate that PRSice-2 is dramatically faster and more memory-efficient than PRSice-1 and alternative PRS software, LDpred and lassosum, while having comparable predictive power. CONCLUSION: PRSice-2's combination of efficiency and power will be increasingly important as data sizes grow and as the applications of PRS become more sophisticated, e.g., when incorporated into high-dimensional or gene set-based analyses. PRSice-2 is written in C++, with an R script for plotting, and is freely available for download from http://PRSice.info.
Strata plot generated by PRSice-2. The X-axis shows the range of different quantiles (e.g., (80,90] corresponds to those individuals with PRS between the 80th and 90th percentile of the population), and the Y-axis shows the odds ratio when comparing PRS from different quantiles with the reference quantile (here, (40,60]), with the bars corresponding to 95% confidence intervals of the odds ratio.
Performance of the 3 PRS software programs on simulated data. (a) Mean run time (in minutes) required to complete the entire analysis, across 10 repeats, when applied to different sizes of target sample. (b) Mean memory (in GB) required for the different software programs to process the different sizes of target sample.
Predictive accuracy of the 3 PRS software programs for a simulated trait with heritability h2 = 0.2, target sample size of 10,000, and base sample size of 50,000. The 3 programs were run using their default parameter settings. The Y-axis represents the trait variance explained (R2) by the PRS generated from each software program, while the X-axis corresponds to the number of causal SNPs for the simulated trait. The horizontal line within boxes corresponds to the median values, while the lower and upper hinges correspond to the lower and upper quartiles, respectively, and the lines extend to the minimum and maximum values if those lie within 1.5 times the inter-quartile range (IQR); if not, then they extend to 1.5 times the IQR. Full results of the comparison study are shown in Supplementary Fig. 2.
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| Citation | PMID | DOI | Status |
|---|---|---|---|
| AllegriniA, SelzamS, RimfeldK, et al. Genomic prediction of cognitive traits in childhood and adolescence. bioRxiv. 2018, doi:10.1101/418210.PMC698635230971729 | — | — | — |
| CecileA, JanssensJW, JoynerMJ Polygenic risk scores that predict common diseases using millions of single nucleotide polymorphisms: Is more, better?. Clin Chem. 2019;65(5):609–11.3080864210.1373/clinchem.2018.296103 | — | — | — |
| ChangCC, ChowCC, TellierLC, et al. Second-generation PLINK: Rising to the challenge of larger and richer datasets. GigaScience. 2015;4:7.2572285210.1186/s13742-015-0047-8PMC4342193 | — | — | — |
| ChoiSW, MakTSH, O'ReillyP A guide to performing Polygenic Risk Score analyses. bioRxiv. 2018, doi:10.1101/416545.PMC761211532709988 | — | — | — |
| ChoiSW, O'ReillyPF Supporting data for “PRSice-2: Polygenic Risk Score Software for Large-Scale Data.”. GigaScience Database. 2019 10.5524/100591.PMC662954231307061 | — | — | — |
| DanciuI, CowanJD, BasfordM, et al. Secondary use of clinical data: The Vanderbilt approach. J Biomed Inform. 2014;52:28–35.2453444310.1016/j.jbi.2014.02.003PMC4133331 | — | — | — |
| Du RietzE, ColemanJ, GlanvilleK, et al. Association of polygenic risk for attention-deficit/hyperactivity disorder with co-occurring traits and disorders. Biol Psychiatry Cogn Neurosci Neuroimaging. 2018;3:635–43.3004747910.1016/j.bpsc.2017.11.013PMC6278881 | — | — | — |
| DuncanL, ShenH, GelayeB, et al. Analysis of polygenic score usage and performance across diverse human populations. bioRxiv. 2018, 10.1101/398396.PMC665847131346163 | — | — | — |
| EuesdenJ, LewisCM, O'ReillyPF PRSice: Polygenic risk score software. Bioinformatics. 2015;31:1466–8.2555032610.1093/bioinformatics/btu848PMC4410663 | — | — | — |
| GeT, ChenC-Y, NiY, et al. Polygenic prediction via Bayesian regression and continuous shrinkage priors. Nat Commun. 2019;10:1776.3099244910.1038/s41467-019-09718-5PMC6467998 | — | — | — |
| HagenaarsSP, HarrisSE, DaviesG, et al. Shared genetic aetiology between cognitive functions and physical and mental health in UK Biobank (N = 112 151) and 24 GWAS consortia. Mol Psychiatry. 2016;21:1624–32.2680984110.1038/mp.2015.225PMC5078856 | — | — | — |
| KaiserJ NIH's 1-million-volunteer precision medicine study announces first pilot projects. Science. 2016 https://www.sciencemag.org/news/2016/02/nih-s-1-million-volunteer-precision-medicine-study-announces-first-pilot-projects. Accessed 15 November 2018 | — | — | — |
| KrapohlE, EuesdenJ, ZabanehD, et al. Phenome-wide analysis of genome-wide polygenic scores. Mol Psychiatry. 2016;21:1188–93.2630366410.1038/mp.2015.126PMC4767701 | — | — | — |
| KrapohlE, PatelH, NewhouseS, et al. Multi-polygenic score approach to trait prediction. Mol Psychiatry. 2018;23:1368–74.2878511110.1038/mp.2017.163PMC5681246 | — | — | — |
| KuchenbaeckerKB, McGuffogL, BarrowdaleD, et al. Evaluation of polygenic risk scores for breast and ovarian cancer risk prediction in BRCA1 and BRCA2 mutation carriers. J Natl Cancer Inst. 2017;109(7), doi:10.1093/jnci/djw302.PMC540899028376175 | — | — | — |
| LiY, WillerC, SannaS, et al. Genotype imputation. Annu Rev Genomics Hum Genet. 2009;10:387–406.1971544010.1146/annurev.genom.9.081307.164242PMC2925172 | — | — | — |
| LockeAE, KahaliB, BerndtSI, et al. Genetic studies of body mass index yield new insights for obesity biology. Nature. 2015;518:197–206.2567341310.1038/nature14177PMC4382211 | — | — | — |
| MakTSH, PorschRM, ChoiSW, et al. Polygenic scores via penalized regression on summary statistics. Genet Epidemiol. 2017;41:469–80.2848097610.1002/gepi.22050 | — | — | — |
| MartinAR, GignouxCR, WaltersRK, et al. Human demographic history impacts genetic risk prediction across diverse populations. Am J Hum Genet. 2017;100:635–49.2836644210.1016/j.ajhg.2017.03.004PMC5384097 | — | — | — |
| MavaddatN, PharoahPDP, MichailidouK, et al. Prediction of breast cancer risk based on profiling with common genetic variants. J Natl Cancer Inst. 2015;107(5), doi:10.1093/jnci/djv036.PMC475462525855707 | — | — | — |
| Márquez‐LunaC, LohP-R, PriceAL Multiethnic polygenic risk scores improve risk prediction in diverse populations. Genet Epidemiol. 2017;41:811–23.2911033010.1002/gepi.22083PMC5726434 | — | — | — |
| NatarajanP, YoungR, StitzielNO, et al. Polygenic risk score identifies subgroup with higher burden of atherosclerosis and greater relative benefit from statin therapy in the primary prevention setting. Circulation. 2017;135(22):2091–101.2822340710.1161/CIRCULATIONAHA.116.024436PMC5484076 | — | — | — |
| NorthBV, CurtisD, ShamPC A note on the calculation of empirical P values from Monte Carlo procedures. Am J Hum Genet. 2002;71:439–41.1211166910.1086/341527PMC379178 | — | — | — |
| Script used for performing simulation presented in the PRSice-2 paper. https://github.com/choishingwan/PRSice-paper-script/tree/30177097ea44b69f5c2cd56ef8beb247e9383db9. | — | — | — |
| SelzamS, DalePS, WagnerRK, et al. Genome-wide polygenic scores predict reading performance throughout the school years. Sci Stud Read. 2017;21:334–49.2870643510.1080/10888438.2017.1299152PMC5490720 | — | — | — |
| SelzamS, KrapohlE, von StummS, et al. Predicting educational achievement from DNA. Mol Psychiatry. 2017;22:267–72.2743129610.1038/mp.2016.107PMC5285461 | — | — | — |
| SudlowC, GallacherJ, AllenN, et al. UK Biobank: An open access resource for identifying the causes of a wide range of complex diseases of middle and old age. PLoS Med. 2015;12:e1001779.2582637910.1371/journal.pmed.1001779PMC4380465 | — | — | — |
| UdlerMS, KimJ, von GrotthussM, et al. Clustering of type 2 diabetes genetic loci by multi-trait associations identifies disease mechanisms and subtypes. bioRxiv. 2018, doi:10.1101/319509.PMC615046330240442 | — | — | — |
| VilhjálmssonBJ, YangJ, FinucaneHK, et al. Modeling linkage disequilibrium increases accuracy of polygenic risk scores. Am J Hum Genet. 2015;97:576–92.2643080310.1016/j.ajhg.2015.09.001PMC4596916 | — | — | — |
| WoodAR, EskoT, YangJ, et al. Defining the role of common variation in the genomic and biological architecture of adult human height. Nat Genet. 2014;46:1173–86.2528210310.1038/ng.3097PMC4250049 | — | — | — |
| WrayNR, LeeSH, MehtaD, et al. Research review: Polygenic methods and their application to psychiatric traits. J Child Psychol Psychiatry. 2014;55:1068–87.2513241010.1111/jcpp.12295 | — | — | — |
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| Exploring the Link Between C-Reactive Protein Change and Stroke Risk: Insights From a Prospective Cohort Study and Genetic Evidence. | Ling Y et al. | — | 2025 | → |
| Exposome-Wide Gene-By-Environment Interaction Study of Psychotic Experiences in the UK Biobank. | Lin BD et al. | — | 2025 | → |
| Familial and genetic relationships of major depressive disorders and adiposity markers in the community. | Berney A et al. | — | 2025 | → |
| Genetic architecture and risk prediction of gestational diabetes mellitus in Chinese pregnancies. | Gu Y et al. | — | 2025 | → |
| Genetic Architecture of Cerebral White Matter Hyperintensities in Diverse Hispanic/Latino Adults. | Fornage M et al. | — | 2025 | → |
| Genetic background and multidomain interventions in mild cognitive impairment. | Fujita K et al. | — | 2025 | → |
| Genetic drivers of hippocampal atrophy highlight the role of APOE functional variants and AD polygenicity in Mild Cognitive Impairment. | Vilor-Tejedor N et al. | — | 2025 | → |
| Genetic Liabilities to Neuropsychiatric Conditions in Suicide Deaths With No Prior Suicidality. | Coon H et al. | — | 2025 | → |
| Genetic liability for anxiety and treatment response to the monoamine stabilizer OSU6162 in alcohol dependence: a retrospective secondary analysis. | Hong MG et al. | — | 2025 | → |
| Genetic predictions of eye and hair colour in the Danish population. | Cabrejas-Olalla A et al. | — | 2025 | → |
| Genetic predisposition to high circulating levels of interleukin 6 and risk for Alzheimer's disease. Discovery and replication. | Charisis S et al. | — | 2025 | → |
| Genetic Predisposition to Hippocampal Atrophy and Risk of Amnestic Mild Cognitive Impairment and Alzheimer's Dementia. | Liampas I et al. | — | 2025 | → |
| Genetic proxies for clinical traits are associated with increased risk of severe COVID-19. | Chaddock NJM et al. | — | 2025 | → |
| Genetic risk and plasma biomarkers of dementia with Lewy bodies in a Chinese population. | Hao X et al. | — | 2025 | → |
| Genetic risk, lifestyle adherence, and risk of developing hyperuricaemia in a Japanese population. | Takase M et al. | — | 2025 | → |
| Genetic Risk Variants for Multiple Sclerosis and Other Loci Linked to Intrathecal Immunoglobulin G Synthesis. | Pukaj A et al. | — | 2025 | → |
| Genetic structure of different ethnic populations at the frontotemporal dementia risk loci. | Mavrych V et al. | — | 2025 | → |
| Genetic Susceptibility to Neurodevelopmental Conditions Is Associated With Neonatal DNA Methylation Patterns in the General Population: An Individual Participant Data Meta-Analysis. | Schuurmans IK et al. | — | 2025 | → |
| Genetic susceptibility to schizophrenia through neuroinflammatory pathways associated with retinal thinness. | Rabe F et al. | — | 2025 | → |
| Genetic Variants and Polygenic Risk Scores Linked to Atopic Dermatitis Risk, Severity, and Serum IgE Levels. | Wei CC et al. | — | 2025 | → |
| Genome-wide analyses of variance in blood cell phenotypes provide new insights into complex trait biology and prediction. | Xiang R et al. | — | 2025 | → |
| Genome-wide analysis of brain age identifies 59 associated loci and unveils relationships with mental and physical health. | Jawinski P et al. | — | 2025 | → |
| Genome-wide association analyses identify candidate loci for amyloid imaging and plasma biomarkers in adults with Down syndrome. | Aslam MM et al. | — | 2025 | → |
| Genome-wide association and DNA methylation analyses of SSRI treatment response in major depressive disorder. | Lyu N et al. | — | 2025 | → |
| Genome-wide association of tau neuroimaging and plasma biomarkers in adults with Down syndrome. | Fan KH et al. | — | 2025 | → |
| Genome-Wide Association Study of Cognitive Function in Population-Based Cohorts in Japan: The Tohoku Medical Megabank Brain Magnetic Resonance Imaging Study. | Shinoda G et al. | — | 2025 | → |
| Genomic and ancestral variations linked to the development of post-acute sequelae of SARS-CoV-2 infection in Indian populations. | Shenoy PU et al. | — | 2025 | → |
| Genotype imputation from low-coverage data for medical and population genetic analyses. | Biagini SA et al. | — | 2025 | → |
| Germline determinants of toxicity and efficacy in patients with large B-cell lymphoma treated with CAR T-cell therapy. | Strati P et al. | — | 2025 | → |
| Gestational Age and Cognitive Development in Childhood. | Nivins S et al. | — | 2025 | → |
| Harmonizing genotype array data to understand genetic risk for brain amyloid burden in the AMYPAD PNHS Consortium. | Luckett ES et al. | — | 2025 | → |
| Healthy lifestyles are associated with alleviating the single-nucleotide polymorphism-based genetic risks of ischaemic stroke, intracerebral haemorrhage and myocardial infarction. | Wang J et al. | — | 2025 | → |
| High level of immunoglobulin G targeting mycoplasma or cytomegalovirus in the newborn increases risk of ADHD. | Borbye-Lorenzen N et al. | — | 2025 | → |
| Hillclimb-Causal Inference: a data-driven approach to identify causal pathways among parental behaviors, genetic risk, and externalizing behaviors in children. | Wei M et al. | — | 2025 | → |
| Hippocampal SGK1 promotes vulnerability to depression: the role of early life adversity, stress, and genetic risk. | Millette A et al. | — | 2025 | → |
| Identification of Novel Genetic Loci Affecting Age at Onset of Parkinson's Disease: A Genome-wide Association Study. | Hwang YS et al. | — | 2025 | → |
| Immune system-associated genes in patients with Alzheimer's disease. | Yao R et al. | — | 2025 | → |
| Impact of the polygenic risk scores for attention-deficit/hyperactivity disorder in Alzheimer's disease. | Leffa DT et al. | — | 2025 | → |
| Improving genetic variant identification for quantitative traits using ensemble learning-based approaches. | Sharma J et al. | — | 2025 | → |
| Improving multi-trait genomic prediction by incorporating local genetic correlations. | Teng J et al. | — | 2025 | → |
| Incidence and Genetic Risk of Juvenile Idiopathic Arthritis in Norway by Latitude. | Hestetun SV et al. | — | 2025 | → |
| Increasing specificity in ADHD genetic association studies during childhood: use of the oxytocin-vasopressin pathway in attentional processes suggests specific mechanism for endophenotypes in the 2004 Pelotas birth (Brazil) cohort. | Camerini L et al. | — | 2025 | → |
| Independent and joint effects of genomic and exposomic loads for schizophrenia on psychotic experiences in adolescents of European ancestry. | Di Vincenzo M et al. | — | 2025 | → |
| Influence of Polygenic Risk on Height and BMI in Adults With a 22q11.2 Microdeletion. | Ying S et al. | — | 2025 | → |
| Insights into ancestral diversity in Parkinson's disease risk: a comparative assessment of polygenic risk scores. | Saffie-Awad P et al. | — | 2025 | → |
| Integrated Transcriptome Analysis Reveals Novel Molecular Signatures for Schizophrenia Characterization. | Ni T et al. | — | 2025 | → |
| Integrating brain imaging features and genomic profiles for the subtyping of major depression. | Yin L et al. | — | 2025 | → |
| Intergenerational transmission of attachment: The role of intelligence. | Runze J et al. | — | 2025 | → |
| Investigating Gene-Environment Interplay Between Bereavement and Polygenic Risk for Attention-Deficit/Hyperactivity Disorder on Externalizing Behaviors During Adolescence. | Espinosa Dice AL et al. | — | 2025 | → |
| Language, Motor Ability and Related Deficits in Children at Familial Risk of Schizophrenia or Bipolar Disorder. | Schiavon M et al. | — | 2025 | → |
| Large language models predict cognition and education close to or better than genomics or expert assessment. | Wolfram T | — | 2025 | → |
| Leveraging haplotype information in heritability estimation and polygenic prediction. | Meisner J et al. | — | 2025 | → |
| Liability threshold model-based disease risk prediction based on electronic health record phenotypes. | Lee CH et al. | — | 2025 | → |
| Linkage and association of preserved cognitive function in the midwestern Amish at a higher genetic risk of Alzheimer's disease. | Dorfsman DA et al. | — | 2025 | → |
| Linking obesity-associated genotype to child language development: the role of early-life neurology-related proteomics and brain myelination. | Huang J et al. | — | 2025 | → |
| Linking polygenic risk scores to dopaminergic neuron loss using neuromelanin-sensitive imaging. | Lanore A et al. | — | 2025 | → |
| Machine Learning Methods for Classifying Multiple Sclerosis and Alzheimer's Disease Using Genomic Data. | Arnal Segura M et al. | — | 2025 | → |
| Mapping Genetic Associations With Functional Brain Area Alterations in Schizophrenia and Implications for Cortical Development. | Zhu JD et al. | — | 2025 | → |
| Mendelian randomization analysis on the impacts of age at menarche on adult height: A Taiwanese population study. | Lukusa MT et al. | — | 2025 | → |
| Methodological validation of Miro1 retention as a candidate Parkinson's disease biomarker. | Drwesh L et al. | — | 2025 | → |
| Migraine and its major subtypes - with and without aura are associated with polygenic scores for autism. | Mohammad S et al. | — | 2025 | → |
| MIP4IBD: An Easy and Rapid Genotyping-by-Sequencing Assay for the Inflammatory Bowel Diseases Risk Loci. | Verstockt S et al. | — | 2025 | → |
| MIR124 polygenic risk and functional connectivity of the striatum in patients with bipolar disorder: mediation by childhood trauma. | Zhong S et al. | — | 2025 | → |
| Modeling gene interactions in polygenic prediction via geometric deep learning. | Li H et al. | — | 2025 | → |
| Molecular hallmarks of excitatory and inhibitory neuronal resilience to Alzheimer's disease. | Castanho I et al. | — | 2025 | → |
| Multi-ancestry genome-wide association analyses of polycystic ovary syndrome. | Zhao H et al. | — | 2025 | → |
| Multi-ancestry genome-wide association meta-analysis identifies novel associations and informs genetic risk prediction for Hirschsprung disease. | Zhong Y et al. | — | 2025 | → |
| Multi-Trait Polygenic Risk Score, Nongenetic Determinants, and Cardiovascular Disease Death: A Cohort Study of 14 086 Japanese Individuals. | Fujii R et al. | — | 2025 | → |
| Multivariate genome-wide analysis reveals shared genetic architecture and brain structural correlates of human cognitive abilities. | Chen H et al. | — | 2025 | → |
| Multivariate genome-wide association analysis of dyslexia and quantitative reading skill improves gene discovery. | Mountford HS et al. | — | 2025 | → |
| Natural selection shaped the protective effect of the mtDNA lineage against obesity in Han Chinese populations. | Chen Z et al. | — | 2025 | → |
| Neurite density but not myelination of specific fiber tracts links polygenic scores to general intelligence. | Stammen C et al. | — | 2025 | → |
| Neurobiological correlates of schizophrenia-specific and highly pleiotropic genetic risk scores for neuropsychiatric disorders. | Federmann LM et al. | — | 2025 | → |
| Next generation sequencing analysis reveals complex genetic architecture of childhood-onset systemic lupus erythematosus. | Lewandowski L et al. | — | 2025 | → |
| Nonlinearity and sex differences in the performance of a polygenic risk score for juvenile idiopathic arthritis. | Haftorn KL et al. | — | 2025 | → |
| Not just old wine in new bottles: Polygenic liability for ADHD is associated with electrophysiological affective-motivational processing beyond anxiety, depression, and ODD. | Ágrez K et al. | — | 2025 | → |
| Novel early-onset Alzheimer-associated genes influence risk through dysregulation of glutamate, immune activation, and intracellular signaling pathways. | Bradley J et al. | — | 2025 | → |
| Novel genetic variants associated with stable isotope-based vitamin B<sub>12</sub> bioavailability measurements in healthy Indian adults. | Sivadas A et al. | — | 2025 | → |
| Obstructive sleep apnea mediates genetic risk of Diabetes Mellitus in Hispanic and Latino communities. | Hrytsenko Y et al. | — | 2025 | → |
| Optimism moderates the relationship between inflammatory polygenic risk and major depressive disorder in U.S. Military veterans. | Fischer IC et al. | — | 2025 | → |
| Pathway insights and predictive modeling for type 2 diabetes using polygenic risk scores. | Liao WL et al. | — | 2025 | → |
| Patient stratification by genetic risk in Alzheimer's disease is only effective in the presence of phenotypic heterogeneity. | Euesden J et al. | — | 2025 | → |
| Penetrance of Parkinson's disease in GBA1 carriers depends on variant severity and polygenic background. | Hassanin E et al. | — | 2025 | → |
| Person-level contributions of bipolar polygenic risk score to the prediction of new-onset bipolar disorder in at-risk offspring. | Hafeman DM et al. | — | 2025 | → |
| PGSXplorer: an integrated nextflow pipeline for comprehensive quality control and polygenic score model development. | Yaraş T et al. | — | 2025 | → |
| Phenotypic expression of rare progressive cardiac conduction disease variants in the general population. | Shah RA et al. | — | 2025 | → |
| Phenotypic heterogeneity in familial epilepsies is influenced by polygenic risk for generalized and focal epilepsies. | Ellis CA et al. | — | 2025 | → |
| Physiological Phenotypic Aging Index and Its Association With Health, Functional, and Health Care Outcomes in Older Adults: Findings From the UK Biobank. | Lee S et al. | — | 2025 | → |
| PIGEON: a statistical framework for estimating gene-environment interaction for polygenic traits. | Miao J et al. | — | 2025 | → |
| Plasma proteomics identifies proteins and pathways associated with incident epilepsy. | Zhang D et al. | — | 2025 | → |
| Polygenic and Polyenvironment Interplay in Schizophrenia-Spectrum Disorder and Affective Psychosis; the EUGEI First Episode Study. | Rodriguez V et al. | — | 2025 | → |
| Polygenic modifiers impact penetrance and expressivity in telomere biology disorders. | Poeschla M et al. | — | 2025 | → |
| Polygenic overlap with granulocyte counts identifies novel loci for clozapine metabolism and clozapine-induced agranulocytosis. | Koch E et al. | — | 2025 | → |
| Polygenic prediction of major depressive disorder and related traits in African ancestries UK Biobank participants. | Kanjira SC et al. | — | 2025 | → |
| Polygenic risk for white matter hyperintensities is associated with early cerebrovascular events partly through hemodynamic measures in cognitively unimpaired middle-aged and older adults with low cardiovascular risk. | Genius P et al. | — | 2025 | → |
| Polygenic risk of idiopathic pulmonary fibrosis and COVID-19 severity. | Guillen-Guio B et al. | — | 2025 | → |
| Polygenic risk score for predicting diabetic retinopathy in patients with type 2 diabetes: A twenty-year follow-up study. | Huang YC et al. | — | 2025 | → |
| Polygenic risk score of Alzheimer's disease is associated with cognitive trajectories and phenotypes of cerebral organoids. | Chun MY et al. | — | 2025 | → |
| Polygenic risk scores in kidney transplantation. | Jelencsics K et al. | — | 2025 | → |
| Polygenic risk scores of fasting insulin and insulin-related traits in a Taiwanese Han population. | Lin WD et al. | — | 2025 | → |
| Polygenic score from MODY genes is associated with type 1 diabetes and disease characteristics. | Catamo E et al. | — | 2025 | → |
| Polygenic score integrating neurodegenerative and vascular risk informs dementia risk stratification. | D'Aoust T et al. | — | 2025 | → |
| Polygenic scores and their applications in kidney disease. | Khan A et al. | — | 2025 | → |
| Polygenic scores of Core 1 Alzheimer's disease biomarkers predict early cognitive and pathological change. | Xu Y et al. | — | 2025 | → |
| Polygenic Scores of Executive Function Provide Limited Support for Genetic Confounding With Socio-Economic Measures. | Perry LC et al. | — | 2025 | → |
| Polygenic transcriptome risk scores enhance predictive accuracy in atopic dermatitis. | Antonatos C et al. | — | 2025 | → |
| Post-traumatic stress and genetic interactions affect tobacco and alcohol use after trauma: findings from a multi-ancestry cohort. | Garrison-Desany HM et al. | — | 2025 | → |
| Predicting the direction of phenotypic difference. | Gokhman D et al. | — | 2025 | → |
| Preliminary Insights Into the Relationship Between the Gut Microbiome and Host Genome in Posttraumatic Stress Disorder. | O'Hare MA et al. | — | 2025 | → |
| Prenatal maternal stress: triangulating evidence for intrauterine exposure effects on birth and early childhood outcomes across multiple approaches. | Lund IO et al. | — | 2025 | → |
| Protective Effects of Genetic Proxies of Cognitive Reserve in Parkinson's Disease: A Longitudinal Multi-Cohort Study. | Huh YE et al. | — | 2025 | → |
| Proteomic insights into metabolic dysfunction-associated steatotic disease: Identifying therapeutic targets and assessing on-target side effects. | Dai L et al. | — | 2025 | → |
| Psychoses of Epilepsy: Unravelling the Phenotypic and Genotypic Features. | Rayner G et al. | — | 2025 | → |
| Recent Advances in Experimental Functional Characterization of GWAS Candidate Genes in Osteoporosis. | Malavašič P et al. | — | 2025 | → |
| Recent Statistical Innovations in Human Genetics. | Balding DJ et al. | — | 2025 | → |
| Recommendations for responsible use of population descriptors in polygenic risk score development. | Smith JL et al. | — | 2025 | → |
| Relationship of Major Depressive Disorder and Schizophrenia Polygenic Risk Scores to Suicide: A Comparison Between European and Asian Ancestry Populations. | Otsuka I et al. | — | 2025 | → |
| Sex difference in genetic risk in the prevalence of atrial fibrillation. | Tokioka S et al. | — | 2025 | → |
| Sex-Specific Polygenic Risk Scores and Replication in a Model-Free Analysis of Schizophrenia Data. | Ott A et al. | — | 2025 | → |
| Sparse polygenic risk score inference with the spike-and-slab LASSO. | Song J et al. | — | 2025 | → |
| Spatial patterns of individual morphological deformation in schizophrenia: Putative cortical compensatory of unaffected sibling. | Yunzhi P et al. | — | 2025 | → |
| Statistical construction of calibrated prediction intervals for polygenic score-based phenotype prediction. | Xu C et al. | — | 2025 | → |
| STREAM-PRS: a multi-tool pipeline for streamlining polygenic risk score computation. | Becelaere S et al. | — | 2025 | → |
| Stress reactivity moderates the association between stressful life events and depressive symptoms in adolescents: Results from a population-based study. | Baltramonaityte V et al. | — | 2025 | → |
| Studying rare variant polygenic risk scores using whole exome sequencing and imputed genotype data. | Kang JO et al. | — | 2025 | → |
| SUDEP risk is influenced by longevity genomics: a polygenic risk score study. | Martins H et al. | — | 2025 | → |
| The association between parental BMI and offspring adiposity: A genetically informed analysis of trios. | Wright L et al. | — | 2025 | → |
| The association of lumbar intervertebral disc degeneration with low back pain is modified by underlying genetic propensity to pain. | Suri P et al. | — | 2025 | → |
| The Evolving Landscape of Functional Models of Autism Spectrum Disorder. | Ranjan J et al. | — | 2025 | → |
| The genetic overlap between major depressive disorder, white blood cell counts and interleukin 6. | Wiström ED et al. | — | 2025 | → |
| The impact of polygenic risk for alzheimer's disease on neurotransmitter-related grey matter atrophy in the alzheimer continuum. | Manca R et al. | — | 2025 | → |
| The neuronal chromatin landscape in brains from individuals with schizophrenia is linked to early fetal development. | Girdhar K et al. | — | 2025 | → |
| The proportion of genetic similarity for liability for neuroticism in mother-child and mother-father dyads is associated with reported relationship quality. | Pearson RM et al. | — | 2025 | → |
| The relationship between autism spectrum disorder and screen time in children: a literature review. | Dilshad A et al. | — | 2025 | → |
| The Role of Energy Homeostasis in Depression Pathophysiology and Its Heterogeneity. | Pistis G et al. | — | 2025 | → |
| The trajectory of attention deficit hyperactivity disorder symptoms and its dynamic relationship with inhibitory control. | Pang T et al. | — | 2025 | → |
| Towards clinical applicability of fMRI via systematic filtering. | Koten JW et al. | — | 2025 | → |
| Toward whole-genome inference of polygenic scores with fast and memory-efficient algorithms. | Zabad S et al. | — | 2025 | → |
| Trans-ancestry genome-wide study of depression identifies 697 associations implicating cell types and pharmacotherapies. | Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium. Electronic address: andrew.mcintosh@ed.ac.uk et al. | — | 2025 | → |
| Trans-ethnic GWAS meta-analysis of idiopathic spermatogenic failure highlights the immune-mediated nature of Sertoli cell-only syndrome. | González-Muñoz S et al. | — | 2025 | → |
| Understanding the Comorbidities Among Psychiatric Disorders, Chronic Low Back Pain, and Spinal Degenerative Disease Using Observational and Genetically Informed Analyses. | Qiu D et al. | — | 2025 | → |
| Unveiling the Causal Relationship between Thyroid and Kidney Function: A Multivariable Mendelian Randomization. | Tsao HM et al. | — | 2025 | → |
| Using Genomics to Develop Personalized Cardiovascular Treatments. | Sanghvi MM et al. | — | 2025 | → |
| Variational autoencoder-based model improves polygenic prediction in blood cell traits. | Li X et al. | — | 2025 | → |
| Abundant pleiotropy across neuroimaging modalities identified through a multivariate genome-wide association study. | Tissink EP et al. | — | 2024 | → |
| Adults prenatally exposed to the Dutch Famine exhibit a metabolic signature associated with a broad spectrum of common diseases. | Taeubert MJ et al. | — | 2024 | → |
| Advancements and limitations in polygenic risk score methods for genomic prediction: a scoping review. | Jayasinghe D et al. | — | 2024 | → |
| A genetic and proteomic comparison of key AD biomarkers across tissues. | Marsh TW et al. | — | 2024 | → |
| A genome-wide association study of neonatal metabolites. | He Q et al. | — | 2024 | → |
| A mediation analysis framework based on variance component to remove genetic confounding effect. | Dong Z et al. | — | 2024 | → |
| A Mendelian Randomization Study: Roles of Gut Microbiota in Sepsis - Who is the Angle? | Bian Y et al. | — | 2024 | → |
| Ancestry-aligned polygenic scores combined with conventional risk factors improve prediction of cardiometabolic outcomes in African populations. | Kamp M et al. | — | 2024 | → |
| An immunogenetic basis for lung cancer risk. | Krishna C et al. | — | 2024 | → |
| An observational and genetic investigation into the association between psoriasis and risk of malignancy. | Li R et al. | — | 2024 | → |
| A perspective on genetic and polygenic risk scores-advances and limitations and overview of associated tools. | Schwarzerova J et al. | — | 2024 | → |
| A Polygenic Risk Analysis for Identifying Ulcerative Colitis Patients with European Ancestry. | Liu L et al. | — | 2024 | → |
| A polygenic risk score for alcohol-associated cirrhosis among heavy drinkers with European ancestry. | Schwantes-An TH et al. | — | 2024 | → |
| Appraising associations between signature lipidomic biomarkers and digestive system cancer risk: novel evidences from a prospective cohort study of UK Biobank and Mendelian randomization analyses. | Sun Y et al. | — | 2024 | → |
| A review of disease risk prediction methods and applications in the omics era. | Sun C et al. | — | 2024 | → |
| Assessing the validity of a self-reported clinical diagnosis of schizophrenia. | Woolway GE et al. | — | 2024 | → |
| Association between genetic risk and adherence to healthy lifestyle for developing age-related hearing loss. | Jung SH et al. | — | 2024 | → |
| Association of Family History and Polygenic Risk Score With Longitudinal Prognosis in Parkinson Disease. | Park M et al. | — | 2024 | → |
| Association of neurotransmitter pathway polygenic risk with specific symptom profiles in psychosis. | Warren TL et al. | — | 2024 | → |
| Association of Occupational Dysfunction and Hospital Admissions With Different Polygenic Profiles in Bipolar Disorder. | Jonsson L et al. | — | 2024 | → |
| Association of polygenic scores for autism with volumetric MRI phenotypes in cerebellum and brainstem in adults. | Mohammad S et al. | — | 2024 | → |
| Association of retinal optical coherence tomography metrics and polygenic risk scores with cognitive function and future cognitive decline. | Sekimitsu S et al. | — | 2024 | → |
| Association of whole-person eigen-polygenic risk scores with Alzheimer's disease. | Kharaghani A et al. | — | 2024 | → |
| Associations of metabolic changes and polygenic risk scores with cardiovascular outcomes and all-cause mortality across BMI categories: a prospective cohort study. | Li C et al. | — | 2024 | → |
| Blood-based epigenome-wide analyses of chronic low-grade inflammation across diverse population cohorts. | Hillary RF et al. | — | 2024 | → |
| Blood-derived mitochondrial DNA copy number is associated with Alzheimer disease, Alzheimer-related biomarkers and serum metabolites. | Tong T et al. | — | 2024 | → |
| Blood Lipid Polygenic Risk Score Development and Application for Atherosclerosis Ultrasound Parameters. | Zaicenoka M et al. | — | 2024 | → |
| BridgePRS leverages shared genetic effects across ancestries to increase polygenic risk score portability. | Hoggart CJ et al. | — | 2024 | → |
| Canadian COVID-19 host genetics cohort replicates known severity associations. | Garg E et al. | — | 2024 | → |
| Causal relationship between blood traits and severe influenza A(H1N1)pdm09 infection in East Asian: A Mendelian randomization study. | Wang F et al. | — | 2024 | → |
| Causal relationships between diseases mined from the literature improve the use of polygenic risk scores. | Toonsi S et al. | — | 2024 | → |
| Cerebral Amyloidosis in Individuals with Subjective Cognitive Decline: From Genetic Predisposition to Actual Cerebrospinal Fluid Measurements. | Sampatakakis SN et al. | — | 2024 | → |
| Characterization of primary Sjögren's syndrome in the Taiwan Han population through a genome-wide association study and polygenic risk score analysis. | Liu TY et al. | — | 2024 | → |
| Charting the shared genetic architecture of Alzheimer's disease, cognition, and educational attainment, and associations with brain development. | Jaholkowski P et al. | — | 2024 | → |
| Clinical Application of Polygenic Risk Score in IgA Nephropathy. | Xu L et al. | — | 2024 | → |
| Clustering Schizophrenia Genes by Their Temporal Expression Patterns Aids Functional Interpretation. | van der Meer D et al. | — | 2024 | → |
| Cognitive impairment in the schizophrenia spectrum: exploring the relationships of the g-factor with sociodemography, psychopathology, neurodevelopment, and genetics. | Yeh D et al. | — | 2024 | → |
| Cognitive Polygenic Index is Associated with Occupational Complexity over and above Brain Morphometry. | Tsapanou A et al. | — | 2024 | → |
| Combined effects of genetic predisposition and sleep quality on acceleration of biological ageing: Findings from the UK biobank cohort. | Zhao C et al. | — | 2024 | → |
| Commonly used genomic arrays may lose information due to imperfect coverage of discovered variants for autism spectrum disorder. | Yao M et al. | — | 2024 | → |
| Common polygenic variation in the early medication change (EMC) cohort affects disorder risk, but not the antidepressant treatment response. | Müller S et al. | — | 2024 | → |
| Comparative analysis of machine learning algorithms for Alzheimer's disease classification using EEG signals and genetic information. | Yu WY et al. | — | 2024 | → |
| Comprehensive Evaluation of the Genetic Basis of Keratoconus: New Perspectives for Clinical Translation. | Cerván-Martín M et al. | — | 2024 | → |
| Contributions of Common Genetic Variants to Constitutional Delay of Puberty and Idiopathic Hypogonadotropic Hypogonadism. | Lippincott MF et al. | — | 2024 | → |
| Corpora amylacea negatively correlate with hippocampal tau pathology in Alzheimer's disease. | Dallmeier JD et al. | — | 2024 | → |
| Data-driven identification of predictive risk biomarkers for subgroups of osteoarthritis using interpretable machine learning. | Nielsen RL et al. | — | 2024 | → |
| Defining type 2 diabetes polygenic risk scores through colocalization and network-based clustering of metabolic trait genetic associations. | Ghatan S et al. | — | 2024 | → |
| Dementia with Lewy Bodies: Genomics, Transcriptomics, and Its Future with Data Science. | Goddard TR et al. | — | 2024 | → |
| Developing a Polygenic Risk Score with Age and Sex to Identify High-Risk Myopia in Taiwan. | Lin HJ et al. | — | 2024 | → |
| Development of a metabolomic risk score for exposure to traffic-related air pollution: A multi-cohort study. | Hoffman SS et al. | — | 2024 | → |
| Development of a Polygenic Risk Score for Metabolic Dysfunction-Associated Steatotic Liver Disease Prediction in UK Biobank. | Giardoglou P et al. | — | 2024 | → |
| Diminished social motivation in early psychosis is associated with polygenic liability for low vitamin D. | Hatzimanolis A et al. | — | 2024 | → |
| Discovery and prioritization of genetic determinants of kidney function in 297,355 individuals from Taiwan and Japan. | Chen HL et al. | — | 2024 | → |
| Disentangling the link between maternal influences on birth weight and disease risk in 36,211 genotyped mother-child pairs. | Leinonen JT et al. | — | 2024 | → |
| Distinct genetic liability profiles define clinically relevant patient strata across common diseases. | Trastulla L et al. | — | 2024 | → |
| Distinguishing vulnerability and resilience to posttraumatic stress disorder evaluating traumatic experiences, genetic risk and electronic health records. | Løkhammer S et al. | — | 2024 | → |
| Donor genetic burden for cerebrovascular risk and kidney transplant outcome. | Collins KE et al. | — | 2024 | → |
| Dopamine Pathway and Parkinson's Risk Variants Are Associated with Levodopa-Induced Dyskinesia. | Sosero YL et al. | — | 2024 | → |
| Dynamics of cognitive variability with age and its genetic underpinning in NIHR BioResource Genes and Cognition cohort participants. | Rahman MS et al. | — | 2024 | → |
| Early life stress modulates the genetic influence on brain structure and cognitive function in children. | Wang HH et al. | — | 2024 | → |
| Effects of polygenic risk score and sodium and potassium intake on hypertension in Asians: A nationwide prospective cohort study. | Bae E et al. | — | 2024 | → |
| En route to conquer the silent killer "hypertension": Integration of polygenic risk score with non-genetic determinants. | Fujii R | — | 2024 | → |
| Epigenetic age acceleration is associated with occupational exposures, sex, and survival in amyotrophic lateral sclerosis. | Zhao Y et al. | — | 2024 | → |
| Ethnic-specific genetic susceptibility loci for endometriosis in Taiwanese-Han population: a genome-wide association study. | Sheu JJ et al. | — | 2024 | → |
| Evaluation of a combined model of Polygenic Risk Score and mismatch repair genes in the association of colorectal cancer for Norwegian cohort. | Akdeniz BC et al. | — | 2024 | → |
| Evaluation of Genetic or Cellular Impairments in Type I IFN Immunity in a Cohort of Young Adults with Critical COVID-19. | Covill LE et al. | — | 2024 | → |
| Evaluation of genomic factors and early childhood stimulation on intelligence in children from a Brazilian birth cohort: The primary role of independent factors. | Sánchez-Luquez KY et al. | — | 2024 | → |
| Evaluation of Polygenic Risk Scores for Prediction of Coronary Artery Disease in a Greek Case-Control Study. | Dimitriou M et al. | — | 2024 | → |
| Examining the Performance of Polygenic Risk Scores for Alzheimer Disease Within and Across Populations Using <i>k</i>-Fold Cross-Validation. | Osterman MD et al. | — | 2024 | → |
| Examining the Role of Neuroticism Polygenic Risk in Late Life Cognitive Change: A UK Biobank Study. | Akbarian N et al. | — | 2024 | → |
| Exome functional risk score and brain connectivity can predict social adaptability outcome of children with autism spectrum disorder in 4 years' follow up. | Luo T et al. | — | 2024 | → |
| Exploring the Genetic Relationship Between Type 2 Diabetes and Cardiovascular Disease: A Large-Scale Genetic Association and Polygenic Risk Score Study. | Yao Z et al. | — | 2024 | → |
| Exploring the Impacts of Age at Menarche on Cognitive Aging in Late Adulthood: Evidence from a Mendelian Randomization Study on the Taiwanese Population. | Fang CW et al. | — | 2024 | → |
| Gene-environment interactions in the influence of maternal education on adolescent neurodevelopment using ABCD study. | Shi R et al. | — | 2024 | → |
| Gene - maltreatment interplay in adult ADHD symptoms: main role of a gene-environment correlation effect in a Brazilian population longitudinal study. | Tovo-Rodrigues L et al. | — | 2024 | → |
| Genetic Analysis of Perceived Youthfulness Reveals Differences in How Men's and Women's Age Is Assessed. | Ingold N et al. | — | 2024 | → |
| Genetic analysis of selection bias in a natural experiment: Investigating in-utero famine effects on elevated body mass index in the Dutch Hunger Winter Families Study. | Zhou J et al. | — | 2024 | → |
| Genetic and inflammatory effects on childhood trauma and cognitive functioning in patients with schizophrenia and healthy participants. | Corley E et al. | — | 2024 | → |
| Genetic and multi-omic resources for Alzheimer disease and related dementia from the Knight Alzheimer Disease Research Center. | Fernandez MV et al. | — | 2024 | → |
| Genetic and phenotypic heterogeneity in early neurodevelopmental traits in the Norwegian Mother, Father and Child Cohort Study. | Hegemann L et al. | — | 2024 | → |
| Genetic and polygenic investigation of heart rate variability to identify biomarkers associated with Anxiety disorders. | Tomasi J et al. | — | 2024 | → |
| Genetic architecture of alcohol consumption identified by a genotype-stratified GWAS and impact on esophageal cancer risk in Japanese people. | Koyanagi YN et al. | — | 2024 | → |
| Genetic Architectures of Adolescent Depression Trajectories in 2 Longitudinal Population Cohorts. | Grimes PZ et al. | — | 2024 | → |
| Genetic basis of pregnancy-associated decreased platelet counts and gestational thrombocytopenia. | Yang Z et al. | — | 2024 | → |
| Genetic characterization of the ALFA study: Uncovering genetic profiles in the Alzheimer's continuum. | Vilor-Tejedor N et al. | — | 2024 | → |
| Genetic influences on circulating retinol and its relationship to human health. | Reay WR et al. | — | 2024 | → |
| Genetic Prediction Modeling in Large Cohort Studies via Boosting Targeted Loss Functions. | Klinkhammer H et al. | — | 2024 | → |
| Genetic Predisposition for White Matter Hyperintensities and Risk of Mild Cognitive Impairment and Alzheimer's Disease: Results from the HELIAD Study. | Sampatakakis SN et al. | — | 2024 | → |
| Genetic risk factors underlying white matter hyperintensities and cortical atrophy. | Patel Y et al. | — | 2024 | → |
| Genetic risk for Alzheimer's disease and adherence to the Mediterranean diet: results from the HELIAD study. | Mamalaki E et al. | — | 2024 | → |
| Genetic risk of type 2 diabetes modifies the association between lifestyle and glycemic health at 5 years postpartum among high-risk women. | Tieu S et al. | — | 2024 | → |
| Genetics of Latin American Diversity Project: Insights into population genetics and association studies in admixed groups in the Americas. | Borda V et al. | — | 2024 | → |
| Genome-wide association analysis and admixture mapping in a Puerto Rican cohort supports an Alzheimer disease risk locus on chromosome 12. | Akgun B et al. | — | 2024 | → |
| Genome-wide association studies and polygenic risk score phenome-wide association studies across complex phenotypes in the human phenotype project. | Levine Z et al. | — | 2024 | → |
| Genome-wide association study and polygenic risk score analysis for schizophrenia in a Korean population. | Lee D et al. | — | 2024 | → |
| Genome-wide association study identifies DRAM1 associated with Tourette syndrome in Taiwan. | Lin WD et al. | — | 2024 | → |
| Genome-wide association study identifies novel susceptible loci and evaluation of polygenic risk score for chronic obstructive pulmonary disease in a Taiwanese population. | Lin WD et al. | — | 2024 | → |
| Genome-wide association study meta-analysis of neurofilament light (NfL) levels in blood reveals novel loci related to neurodegeneration. | Ahmad S et al. | — | 2024 | → |
| Genome-wide association study of early-onset and late-onset postpartum depression: the IGEDEPP prospective study. | Tebeka S et al. | — | 2024 | → |
| Genome-Wide Association Study of Obsessive-Compulsive Symptoms including 33,943 individuals from the general population. | Strom NI et al. | — | 2024 | → |
| Genome-Wide Association Study Points to Novel Locus for Gilles de la Tourette Syndrome. | Tsetsos F et al. | — | 2024 | → |
| Genotype-environment interplay in associations between maternal drinking and offspring emotional and behavioral problems. | Hannigan LJ et al. | — | 2024 | → |
| Geographic variation of mutagenic exposures in kidney cancer genomes. | Senkin S et al. | — | 2024 | → |
| GWAS Identifies DPP6 as Risk Gene of Cognitive Decline in Parkinson's Disease. | Li C et al. | — | 2024 | → |
| Identification of Genetic Variants for Risk Prediction and Early Diagnosis of Age-Related Macular Degeneration in the Taiwanese Population. | Huang YC et al. | — | 2024 | → |
| Identification of novel genomic loci for anxiety symptoms and extensive genetic overlap with psychiatric disorders. | Tesfaye M et al. | — | 2024 | → |
| Identifying potential causal effects of Parkinson's disease: A polygenic risk score-based phenome-wide association and mendelian randomization study in UK Biobank. | Shi C et al. | — | 2024 | → |
| Improving polygenic risk prediction in admixed populations by explicitly modeling ancestral-differential effects via GAUDI. | Sun Q et al. | — | 2024 | → |
| Imputation Server PGS: an automated approach to calculate polygenic risk scores on imputation servers. | Forer L et al. | — | 2024 | → |
| Individual cereals intake is associated with progression of diabetes and diabetic chronic complications. | Tang S et al. | — | 2024 | → |
| Inflation of polygenic risk scores caused by sample overlap and relatedness: Examples of a major risk of bias. | Ellis CA et al. | — | 2024 | → |
| Influence of TMX2-CTNND1 polymorphism on cortical thickness in schizophrenia patients and unaffected siblings: an exploratory study based on target region sequencing. | Tan W et al. | — | 2024 | → |
| Infrastructuring Educational Genomics: Associations, Architectures, and Apparatuses. | Williamson B et al. | — | 2024 | → |
| Integration of a polygenic score into guideline-recommended prediction of cardiovascular disease. | Li L et al. | — | 2024 | → |
| Integration of polygenic and gut metagenomic risk prediction for common diseases. | Liu Y et al. | — | 2024 | → |
| Interactive effect of air pollution and genetic risk of depression on processing speed by resting-state functional connectivity of occipitoparietal network. | Zhang Y et al. | — | 2024 | → |
| Interplay between polygenic risk for mood disorders and stressful life events in bipolar disorder. | Hosang GM et al. | — | 2024 | → |
| Intrauterine growth and the tangential expansion of the human cerebral cortex in times of food scarcity and abundance. | Vosberg DE et al. | — | 2024 | → |
| Investigating the effect of polygenic background on epilepsy phenotype in 'monogenic' families. | Oliver KL et al. | — | 2024 | → |
| Investigating the link between gut microbiome and bone mineral density: The role of genetic factors. | Gao N et al. | — | 2024 | → |
| Investigating the Relationship Between Smoking Behavior and Global Brain Volume. | Chang Y et al. | — | 2024 | → |
| Investigation of genetic determinants of cognitive change in later life. | Mahedy L et al. | — | 2024 | → |
| Investigation of the genetic aetiology of Lewy body diseases with and without dementia. | Wu LY et al. | — | 2024 | → |
| Large-scale metagenomic analysis of oral microbiomes reveals markers for autism spectrum disorders. | Manghi P et al. | — | 2024 | → |
| Long-term ambient air pollution and the risk of major mental disorder: A prospective cohort study. | Pan C et al. | — | 2024 | → |
| Long-term impact of digital media on brain development in children. | Nivins S et al. | — | 2024 | → |
| Maternal seafood intake, dietary contaminant exposure, and risk of juvenile idiopathic arthritis: exploring gene-environment interactions. | Dåstøl VØ et al. | — | 2024 | → |
| Mechanism-free repurposing of drugs for C9orf72-related ALS/FTD using large-scale genomic data. | Saez-Atienzar S et al. | — | 2024 | → |
| Mendelian randomization study of the relationship between blood and urine biomarkers and schizophrenia in the UK Biobank cohort. | Cheng B et al. | — | 2024 | → |
| Meta-analysis of ACE inhibitor-induced angioedema identifies novel risk locus. | Mathey CM et al. | — | 2024 | → |
| Metabolic gene function discovery platform GeneMAP identifies SLC25A48 as necessary for mitochondrial choline import. | Khan A et al. | — | 2024 | → |
| Methodologies underpinning polygenic risk scores estimation: a comprehensive overview. | Ndong Sima CAA et al. | — | 2024 | → |
| Molecular monitoring of short- and long-term transcriptional effects of hair growth stimulating agents. | Henne SK et al. | — | 2024 | → |
| Multiomics Analyses Reveal Microbiome-Gut-Brain Crosstalk Centered on Aberrant Gamma-Aminobutyric Acid and Tryptophan Metabolism in Drug-Naïve Patients with First-Episode Schizophrenia. | Wang Z et al. | — | 2024 | → |
| Multiple polygenic risk scores can improve the prediction of systemic lupus erythematosus in Taiwan. | Chen YC et al. | — | 2024 | → |
| Multi-polygenic scores in psychiatry: From disorder specific to transdiagnostic perspectives. | Shi Y et al. | — | 2024 | → |
| Multivariate genomic analysis of 5 million people elucidates the genetic architecture of shared components of the metabolic syndrome. | Park S et al. | — | 2024 | → |
| NeuroBooster Array: A Genome-Wide Genotyping Platform to Study Neurological Disorders Across Diverse Populations. | Bandres-Ciga S et al. | — | 2024 | → |
| Neuroticism polygenic risk predicts conversion from mild cognitive impairment to Alzheimer's disease by impairing inferior parietal surface area. | Li Q et al. | — | 2024 | → |
| No increase of CD8+ TEMRA cells in the blood of healthy adults at high genetic risk of Alzheimer's disease. | Deecke L et al. | — | 2024 | → |
| No Replication of Alzheimer's Disease Genetics as a Moderator of Combat Exposure's Association with PTSD risk in 138,592 Combat Veterans. | Wolf EJ et al. | — | 2024 | → |
| Obesity-enriched gut microbe degrades myo-inositol and promotes lipid absorption. | Wu C et al. | — | 2024 | → |
| [Online phenotypes of depression symptoms are associated with polygenic risk scores of somatic diseases in a population-based cohort]. | Kibitov AO et al. | — | 2024 | → |
| Parkinson's families project: a UK-wide study of early onset and familial Parkinson's disease. | Towns C et al. | — | 2024 | → |
| Pediatric Features of Genetic Predisposition to Polycystic Ovary Syndrome. | Zhu J et al. | — | 2024 | → |
| Persistent thinness and anorexia nervosa differ on a genomic level. | Hübel C et al. | — | 2024 | → |
| Person-specific differences in ubiquitin-proteasome mediated proteostasis in human neurons. | Hsieh YC et al. | — | 2024 | → |
| Pharmacogenomics polygenic risk score: Ready or not for prime time? | Singh S et al. | — | 2024 | → |
| Polygenic prediction of human longevity on the supposition of pervasive pleiotropy. | Jabalameli MR et al. | — | 2024 | → |
| Polygenic risk and rare variant gene clustering enhance cancer risk stratification for breast and prostate cancers. | Kang JH et al. | — | 2024 | → |
| Polygenic risk associated with Alzheimer's disease and other traits influences genes involved in T cell signaling and activation. | Dressman D et al. | — | 2024 | → |
| Polygenic Risk Associations with Clinical Characteristics and Recurrence of Dupuytren Disease. | Riesmeijer SA et al. | — | 2024 | → |
| Polygenic risk for major depression, attention deficit hyperactivity disorder, neuroticism, and schizophrenia are correlated with experience of intimate partner violence. | Ratanatharathorn A et al. | — | 2024 | → |
| Polygenic Risk for Type 2 Diabetes in African Americans. | Irvin MR et al. | — | 2024 | → |
| Polygenic risk of social isolation behavior and its influence on psychopathology and personality. | Socrates AJ et al. | — | 2024 | → |
| Polygenic Risk Score Associates With Atherosclerotic Plaque Characteristics at Autopsy. | Cornelissen A et al. | — | 2024 | → |
| Polygenic risk score-based phenome-wide association for glaucoma and its impact on disease susceptibility in two large biobanks. | Yun JS et al. | — | 2024 | → |
| Polygenic Risk Score, Cardiorespiratory Fitness, and Cardiometabolic Risk Factors: WASEDA'S Health Study. | Tanisawa K et al. | — | 2024 | → |
| Polygenic risk score for blood pressure and lifestyle factors with overall and CVD mortality: a prospective cohort study in a Japanese population. | Fujii R et al. | — | 2024 | → |
| Polygenic risk score predicts all-cause death in East Asian patients with prior coronary artery disease. | Qin M et al. | — | 2024 | → |
| Polygenic Risk Score Predicts Earlier-Onset Adult Systemic Lupus Erythematosus and First-Year Renal Diseases in a Taiwanese Cohort. | Chen YJ et al. | — | 2024 | → |
| Polygenic Risk Scores Validated in Patient-Derived Cells Stratify for Mitochondrial Subtypes of Parkinson's Disease. | Arena G et al. | — | 2024 | → |
| Polygenic Score for Conscientiousness Is a Protective Factor for Reversion from Mild Cognitive Impairment to Normal Cognition. | Yang X et al. | — | 2024 | → |
| Polygenic scores and Mendelian randomization identify plasma proteins causally implicated in Alzheimer's disease. | Cammann DB et al. | — | 2024 | → |
| Polygenic scores of subcortical brain volumes as possible modulators of treatment response in depression. | Oliva V et al. | — | 2024 | → |
| Polygenic scores stratify neurodevelopmental copy number variant carrier cognitive outcomes in the UK Biobank. | Dinneen TJ et al. | — | 2024 | → |
| Polygenic susceptibility for multiple sclerosis is associated with working memory in low-performing young adults. | Petrovska J et al. | — | 2024 | → |
| Population clustering of structural brain aging and its association with brain development. | Duan H et al. | — | 2024 | → |
| Principles and methods for transferring polygenic risk scores across global populations. | Kachuri L et al. | — | 2024 | → |
| Proteo-genomics of soluble TREM2 in cerebrospinal fluid provides novel insights and identifies novel modulators for Alzheimer's disease. | Wang L et al. | — | 2024 | → |
| Psychosocial moderators of polygenic risk scores of inflammatory biomarkers in relation to GrimAge. | Tamman AJF et al. | — | 2024 | → |
| Rare-variant and polygenic analyses of amyotrophic lateral sclerosis in the French-Canadian genome. | Ross JP et al. | — | 2024 | → |
| Rare variant association analyses reveal the significant contribution of carbohydrate metabolic disturbance in severe adolescent idiopathic scoliosis. | Wen W et al. | — | 2024 | → |
| Regulatory elements in <i>SEM1-DLX5-DLX6</i> (7q21.3) locus contribute to genetic control of coronal nonsyndromic craniosynostosis and bone density-related traits. | Nicoletti P et al. | — | 2024 | → |
| Revealing the genetic complexity of hypothyroidism: integrating complementary association methods. | Zucker R et al. | — | 2024 | → |
| Risk Factors, Prognosis, Influence on the Offspring, and Genetic Architecture of Perinatal Depression Classified Based on the Depressive Symptom Trajectory. | Ohseto H et al. | — | 2024 | → |
| Risk prediction and interaction analysis using polygenic risk score of type 2 diabetes in a Korean population. | Song M et al. | — | 2024 | → |
| Rome III Criteria Capture Higher Irritable Bowel Syndrome SNP-Heritability and Highlight a Novel Genetic Link With Cardiovascular Traits. | Camargo Tavares L et al. | — | 2024 | → |
| Schizophrenia polygenic risk scores, clinical variables and genetic pathways as predictors of phenotypic traits of bipolar I disorder. | Grigoroiu-Serbanescu M et al. | — | 2024 | → |
| Shared genetic etiology between ADHD, task-related behavioral measures and brain activation during response inhibition in a youth ADHD case-control study. | Saraçaydın G et al. | — | 2024 | → |
| Shared genetic mechanisms underlying association between sleep disturbances and depressive symptoms. | Moyses-Oliveira M et al. | — | 2024 | → |
| Stacked neural network for predicting polygenic risk score. | Kim SB et al. | — | 2024 | → |
| Systemic inflammation and risk of Parkinson's disease: A prospective cohort study and genetic analysis. | Li C et al. | — | 2024 | → |
| Telomere length and cognitive changes in 7,877 older UK adults of European ancestry. | Packer A et al. | — | 2024 | → |
| Thalamocortical organoids enable in vitro modeling of 22q11.2 microdeletion associated with neuropsychiatric disorders. | Shin D et al. | — | 2024 | → |
| The Add Health Parent Study: A Biosocial Resource for the Study of Multigenerational Racial/Ethnic Disparities in Alzheimer's Disease and Alzheimer's Disease-Related Dementias. | Perreira KM et al. | — | 2024 | → |
| The effect of family structure on the still-missing heritability and genomic prediction accuracy of type 2 diabetes. | Amiri Roudbar M et al. | — | 2024 | → |
| The effect of polygenic risk score and childhood adversity on transdiagnostic symptom dimensions at first-episode psychosis: evidence for an affective pathway to psychosis. | Alameda L et al. | — | 2024 | → |
| The genetic architecture of youth anxiety: a study protocol. | McAusland L et al. | — | 2024 | → |
| The GenoPred pipeline: a comprehensive and scalable pipeline for polygenic scoring. | Pain O et al. | — | 2024 | → |
| The impact of assortative mating, participation bias and socioeconomic status on the polygenic risk of behavioural and psychiatric traits. | Cabrera-Mendoza B et al. | — | 2024 | → |
| The impact of major depressive disorder on glycaemic control in type 2 diabetes: a longitudinal cohort study using UK Biobank primary care records. | Gillett AC et al. | — | 2024 | → |
| The neural and genetic underpinnings of different developmental trajectories of Attention-Deficit/Hyperactivity Symptoms in children and adolescents. | Wang Y et al. | — | 2024 | → |
| The role of environmental sensitivity in the mental health of Syrian refugee children: a multi-level analysis. | May AK et al. | — | 2024 | → |
| The structure of psychiatric comorbidity without selection and assortative mating. | Ayorech Z et al. | — | 2024 | → |
| The utility of obesity polygenic risk scores from research to clinical practice: A review. | Jansen PR et al. | — | 2024 | → |
| Trans-ancestral genome-wide association study of longitudinal pubertal height growth and shared heritability with adult health outcomes. | Bradfield JP et al. | — | 2024 | → |
| Transcriptomic changes in oligodendrocytes and precursor cells associate with clinical outcomes of Parkinson's disease. | Dehestani M et al. | — | 2024 | → |
| Traumatic Brain Injury and Genetic Risk for Alzheimer's Disease Impact Cerebrospinal Fluid β-Amyloid Levels in Vietnam War Veterans. | Moody JN et al. | — | 2024 | → |
| Unveiling the molecular landscape of cognitive aging: insights from polygenic risk scores, DNA methylation, and gene expression. | Neto S et al. | — | 2024 | → |
| Utility of polygenic scores across diverse diseases in a hospital cohort for predictive modeling. | Sun TH et al. | — | 2024 | → |
| Variability in performance of genetic-enhanced DXA-BMD prediction models across diverse ethnic and geographic populations: A risk prediction study. | Liu Y et al. | — | 2024 | → |
| Vitamin D, Cognition, and Alzheimer's Disease: Observational and Two-Sample Mendelian Randomization Studies. | Ilboudo Y et al. | — | 2024 | → |
| Whole exome sequencing analyses identified novel genes for Alzheimer's disease and related dementia. | Zhang YR et al. | — | 2024 | → |
| Whole genome sequencing analysis identifies sex differences of familial pattern contributing to phenotypic diversity in autism. | Kim SW et al. | — | 2024 | → |
| Worldwide distribution of genetic factors related to severity of COVID-19 infection. | Esteban ME et al. | — | 2024 | → |
| A biologically informed polygenic score of neuronal plasticity moderates the association between cognitive aptitudes and cortical thickness in adolescents. | Navarri X et al. | — | 2023 | → |
| A Breast Cancer Polygenic Risk Score Is Feasible for Risk Stratification in the Norwegian Population. | Akdeniz BC et al. | — | 2023 | → |
| Accelerated biological aging and risk of depression and anxiety: evidence from 424,299 UK Biobank participants. | Gao X et al. | — | 2023 | → |
| Accuracy of haplotype estimation and whole genome imputation affects complex trait analyses in complex biobanks. | Appadurai V et al. | — | 2023 | → |
| A genome-wide association, polygenic risk score and sex study on opioid use disorder treatment outcomes. | McEvoy A et al. | — | 2023 | → |
| A genome-wide association study of antidepressant-induced mania. | Zai CC et al. | — | 2023 | → |
| AI-based multi-PRS models outperform classical single-PRS models. | Klau JH et al. | — | 2023 | → |
| Air pollution exposure during pregnancy and childhood, APOE ε4 status and Alzheimer polygenic risk score, and brain structural morphology in preadolescents. | Essers E et al. | — | 2023 | → |
| Alzheimer's disease and related dementias among aging veterans: Examining gene-by-environment interactions with post-traumatic stress disorder and traumatic brain injury. | Logue MW et al. | — | 2023 | → |
| Alzheimer's disease genetic burden is associated with mid-life depression among persons with normal cognition. | Wingo TS et al. | — | 2023 | → |
| A multivariate genome-wide association study of psycho-cardiometabolic multimorbidity. | Baltramonaityte V et al. | — | 2023 | → |
| Analysis of 72,469 UK Biobank exomes links rare variants to male-pattern hair loss. | Henne SK et al. | — | 2023 | → |
| A new 165-SNP low-density lipoprotein cholesterol polygenic risk score based on next generation sequencing outperforms previously published scores in routine diagnostics of familial hypercholesterolemia. | Vanhoye X et al. | — | 2023 | → |
| An integrated multi-omics analysis of sleep-disordered breathing traits implicates P2XR4 purinergic signaling. | Kurniansyah N et al. | — | 2023 | → |
| A pilot pharmacogenetic study of calcium channel blocker treatment of bipolar mania. | Li M et al. | — | 2023 | → |
| A polygenic risk score for Alzheimer's disease constructed using APOE-region variants has stronger association than APOE alleles with mild cognitive impairment in Hispanic/Latino adults in the U.S. | Sofer T et al. | — | 2023 | → |
| A polygenic risk score to help discriminate primary adrenal insufficiency of different etiologies. | Aranda-Guillén M et al. | — | 2023 | → |
| A sex-specific genome-wide association study of depression phenotypes in UK Biobank. | Silveira PP et al. | — | 2023 | → |
| Assessing the performance of European-derived cardiometabolic polygenic risk scores in South-Asians and their interplay with family history. | Hassanin E et al. | — | 2023 | → |
| Associated Genetics and Connectomic Circuitry in Schizophrenia and Bipolar Disorder. | Wei Y et al. | — | 2023 | → |
| Associating broad and clinically defined polygenic scores for depression with depression-related phenotypes. | McGeary JE et al. | — | 2023 | → |
| Association between brain similarity to severe mental illnesses and comorbid cerebral, physical, and cognitive impairments. | Ma Y et al. | — | 2023 | → |
| Association between polygenic risk for Alzheimer's disease and brain structure in children and adults. | He XY et al. | — | 2023 | → |
| Association of Cognitive Polygenic Index and Cognitive Performance with Age in Cognitively Healthy Adults. | Tsapanou A et al. | — | 2023 | → |
| Association of Combined Exposure to Ambient Air Pollutants, Genetic Risk, and Incident Rheumatoid Arthritis: A Prospective Cohort Study in the UK Biobank. | Zhang J et al. | — | 2023 | → |
| Association of mitochondrial DNA variation with high myopia in a Han Chinese population. | Xing S et al. | — | 2023 | → |
| Association of polygenic scores for depression and neuroticism with perceived stress in daily life during a long-lasting stress period. | Peter HL et al. | — | 2023 | → |
| Association of premorbid intelligence with level of functioning and illness severity in bipolar disorder. | Smedler E et al. | — | 2023 | → |
| Associations Between Symptoms of Premenstrual Disorders and Polygenic Liability for Major Psychiatric Disorders. | Jaholkowski P et al. | — | 2023 | → |
| A statistical genetic investigation of psychiatric resilience. | Cusack SE et al. | — | 2023 | → |
| A study of the genetic architecture of social responsiveness in families with parental schizophrenia or bipolar disorder and population-based controls. | Veddum L et al. | — | 2023 | → |
| Atopic Polygenic Risk Score Is Associated with Paradoxical Eczema Developing in Patients with Psoriasis Treated with Biologics. | Al-Janabi A et al. | — | 2023 | → |
| Biomarkers selection and mathematical modeling in biological age estimation. | Bafei SEC et al. | — | 2023 | → |
| Brain structure, phenotypic and genetic correlates of reading performance. | Carrión-Castillo A et al. | — | 2023 | → |
| Case-case genome-wide association analysis identifying genetic loci with divergent effects on Crohn's disease and ulcerative colitis. | Jung S et al. | — | 2023 | → |
| Causal Influences of Same-Sex Attraction on Psychological Distress and Risky Sexual Behaviors: Evidence for Bidirectional Effects. | Oginni OA et al. | — | 2023 | → |
| Characterization and prediction of individual functional outcome trajectories in schizophrenia spectrum disorders (PREDICTS study): Study protocol. | Agarwal SM et al. | — | 2023 | → |
| Childhood trajectories of internalising and externalising problems associated with a polygenic risk score for neuroticism in a UK birth cohort study. | Costantini I et al. | — | 2023 | → |
| Clinical applications of polygenic risk score for coronary artery disease through the life course. | Fahed AC et al. | — | 2023 | → |
| Clinical utility of polygenic risk scores: a critical 2023 appraisal. | Koch S et al. | — | 2023 | → |
| Clinical utility of polygenic scores for cardiometabolic disease in Arabs. | Shim I et al. | — | 2023 | → |
| Clonal Hematopoiesis and Risk of Incident Lung Cancer. | Tian R et al. | — | 2023 | → |
| Cluster Headache Genomewide Association Study and Meta-Analysis Identifies Eight Loci and Implicates Smoking as Causal Risk Factor. | Winsvold BS et al. | — | 2023 | → |
| Combining polygenic risk scores and human leukocyte antigen variants for personalized risk assessment of type 1 diabetes in the Taiwanese population. | Liao WL et al. | — | 2023 | → |
| Common genetic variations in telomere length genes and lung cancer: a Mendelian randomisation study and its novel application in lung tumour transcriptome. | Cortez Cardoso Penha R et al. | — | 2023 | → |
| Comparing Pruning and Thresholding with Continuous Shrinkage Polygenic Score Methods in a Large Sample of Ancestrally Diverse Adolescents from the ABCD Study<sup>®</sup>. | Ahern J et al. | — | 2023 | → |
| Computational Modeling of the n-Back Task in the ABCD Study: Associations of Drift Diffusion Model Parameters to Polygenic Scores of Mental Disorders and Cardiometabolic Diseases. | Pedersen ML et al. | — | 2023 | → |
| Cross-ancestry genome-wide association meta-analyses of hippocampal and subfield volumes. | Liu N et al. | — | 2023 | → |
| Cross-phenotype relationship between opioid use disorder and suicide attempts: new evidence from polygenic association and Mendelian randomization analyses. | Huang Y et al. | — | 2023 | → |
| Cumulative Genetic Score and <i>C9orf72</i> Repeat Status Independently Contribute to Amyotrophic Lateral Sclerosis Risk in 2 Case-Control Studies. | Dou J et al. | — | 2023 | → |
| DeepGAMI: deep biologically guided auxiliary learning for multimodal integration and imputation to improve genotype-phenotype prediction. | Chandrashekar PB et al. | — | 2023 | → |
| Deep Learning for Cross-Diagnostic Prediction of Mental Disorder Diagnosis and Prognosis Using Danish Nationwide Register and Genetic Data. | Allesøe RL et al. | — | 2023 | → |
| Developmental manifestations of polygenic risk for bipolar disorder from infancy to middle childhood. | Askeland RB et al. | — | 2023 | → |
| Development of a Polygenic Risk Score for BMI to Assess the Genetic Susceptibility to Obesity and Related Diseases in the Korean Population. | Yoon N et al. | — | 2023 | → |
| Different types of milk consumption and the risk of dementia: Analysis from a large-scale cohort study. | Deng Z et al. | — | 2023 | → |
| Dissecting the genetic heterogeneity of gastric cancer. | Hess T et al. | — | 2023 | → |
| Dissecting the mediating and moderating effects of depression on the associations between traits and coronary artery disease: A two-step Mendelian randomization and phenome-wide interaction study. | Zheng X et al. | — | 2023 | → |
| Dissecting the polygenic basis of atherosclerosis via disease-associated cell state signatures. | Örd T et al. | — | 2023 | → |
| DNA Methylation Age Acceleration as a Potential Biomarker for Early Onset of Rapid Eye Movement Sleep Behavior Disorder. | Senkevich K et al. | — | 2023 | → |
| DNA Methylation Signatures of Multiple Sclerosis Occur Independently of Known Genetic Risk and Are Primarily Attributed to B Cells and Monocytes. | Xavier A et al. | — | 2023 | → |
| Early prediction of prostate cancer risk in younger men using polygenic risk scores and electronic health records. | Varma A et al. | — | 2023 | → |
| Effect of schizophrenia common variants on infant brain volumes: cross-sectional study in 207 term neonates in developing Human Connectome Project. | Le H et al. | — | 2023 | → |
| Epidemiologic and Genetic Associations of Endometriosis With Depression, Anxiety, and Eating Disorders. | Koller D et al. | — | 2023 | → |
| Evaluating the use of blood pressure polygenic risk scores across race/ethnic background groups. | Kurniansyah N et al. | — | 2023 | → |
| Evaluation of optimal methods and ancestries for calculating polygenic risk scores in East Asian population. | Kim DJ et al. | — | 2023 | → |
| Evaluation of polygenic risk scores to differentiate between type 1 and type 2 diabetes. | Shoaib M et al. | — | 2023 | → |
| Evidence for a shared genetic contribution to loneliness and borderline personality disorder. | Schulze A et al. | — | 2023 | → |
| Evidence of the folate-mediated one-carbon metabolism pathway genes in controlling the non-syndromic oral clefts risks. | Wang S et al. | — | 2023 | → |
| Exploring the association and causal effect between white blood cells and psoriasis using large-scale population data. | Zhou G et al. | — | 2023 | → |
| Exploring the overlap between alopecia areata and major depressive disorder: Epidemiological and genetic perspectives. | Foo JC et al. | — | 2023 | → |
| Extra cup of tea intake associated with increased risk of Alzheimer's disease: Genetic insights from Mendelian randomization. | Sun Y et al. | — | 2023 | → |
| FairPRS: adjusting for admixed populations in polygenic risk scores using invariant risk minimization. | Machado Reyes D et al. | — | 2023 | → |
| Familial Mesial Temporal Lobe Epilepsy: Clinical Spectrum and Genetic Evidence for a Polygenic Architecture. | Harris RV et al. | — | 2023 | → |
| Family-based analysis of the contribution of rare and common genetic variants to school performance in schizophrenia. | Rammos A et al. | — | 2023 | → |
| Fast and accurate Bayesian polygenic risk modeling with variational inference. | Zabad S et al. | — | 2023 | → |
| First-Episode Psychosis Patients Who Deteriorated in the Premorbid Period Do Not Have Higher Polygenic Risk Scores Than Others: A Cluster Analysis of EU-GEI Data. | Ferraro L et al. | — | 2023 | → |
| Founder population-specific weights yield improvements in performance of polygenic risk scores for Alzheimer disease in the Midwestern Amish. | Osterman MD et al. | — | 2023 | → |
| Frailty Resilience Score: A Novel Measure of Frailty Resilience Associated With Protection From Frailty and Survival. | Milman S et al. | — | 2023 | → |
| Functional characterization of Alzheimer's disease genetic variants in microglia. | Yang X et al. | — | 2023 | → |
| Gender differences in the association between parity and cognitive function: Evidence from the UK biobank. | Zhang Y et al. | — | 2023 | → |
| Genetic and epidemiological analyses of infection load and its relationship with psychiatric disorders. | Nudel R et al. | — | 2023 | → |
| Genetic and Structural Brain Correlates of Cognitive Subtypes Across Youth at Family Risk for Schizophrenia and Bipolar Disorder. | Valli I et al. | — | 2023 | → |
| Genetic Architecture of Ischaemic Strokes after COVID-19 Shows Similarities with Large Vessel Strokes. | Llucià-Carol L et al. | — | 2023 | → |
| Genetic architecture of spatial electrical biomarkers for cardiac arrhythmia and relationship with cardiovascular disease. | Young WJ et al. | — | 2023 | → |
| Genetic associations between sleep traits and cognitive ageing outcomes in the Hispanic Community Health Study/Study of Latinos. | Zhang Y et al. | — | 2023 | → |
| Genetic contributions to female gout and hyperuricaemia using genome-wide association study and polygenic risk score analyses. | Lin CY et al. | — | 2023 | → |
| Genetic correlations between Alzheimer's disease and gut microbiome genera. | Cammann D et al. | — | 2023 | → |
| Genetic Inheritance Models of Non-Syndromic Cleft Lip with or without Palate: From Monogenic to Polygenic. | Cheng X et al. | — | 2023 | → |
| Genetic landscape of Parkinson's disease and related diseases in Luxembourg. | Landoulsi Z et al. | — | 2023 | → |
| Genetic liability to suicidal thoughts and behaviors and risk of suicide attempt in US military veterans: moderating effects of cumulative trauma burden. | Nichter B et al. | — | 2023 | → |
| Genetic Modifiers of Age at Onset for Amyotrophic Lateral Sclerosis: A Genome-Wide Association Study. | Li C et al. | — | 2023 | → |
| Genetic patterning for child psychopathology is distinct from that for adults and implicates fetal cerebellar development. | Hughes DE et al. | — | 2023 | → |
| Genetic predisposition to major depressive disorder differentially impacts alcohol consumption and high-risk drinking situations in men and women with alcohol use disorder. | Karpyak VM et al. | — | 2023 | → |
| Genetic relationship between the immune system and autism. | Arenella M et al. | — | 2023 | → |
| Genetic Risk, Adherence to a Healthy Lifestyle, and Hyperuricemia: The TCLSIH Cohort Study. | Zhang T et al. | — | 2023 | → |
| Genetics of cannabis use in opioid use disorder: A genome-wide association and polygenic risk score study. | Hillmer A et al. | — | 2023 | → |
| Genetic variants in HFE are associated with non-alcoholic fatty liver disease in lean individuals. | Sun Z et al. | — | 2023 | → |
| Genome- and transcriptome-wide splicing associations with alcohol use disorder. | Huggett SB et al. | — | 2023 | → |
| Genome-wide analyses identify NEAT1 as genetic modifier of age at onset of amyotrophic lateral sclerosis. | Li C et al. | — | 2023 | → |
| Genome-wide analyses reveal novel opioid use disorder loci and genetic overlap with schizophrenia, bipolar disorder, and major depression. | Holen B et al. | — | 2023 | → |
| Genome-wide association analyses identified novel susceptibility loci for pulmonary embolism among Han Chinese population. | Zhang Z et al. | — | 2023 | → |
| Genome-wide association study in 404,302 individuals identifies 7 significant loci for reaction time variability. | Wootton O et al. | — | 2023 | → |
| Genome-wide association study meta-analysis of suicide death and suicidal behavior. | Li QS et al. | — | 2023 | → |
| Genome-wide association study using whole-genome sequencing identifies risk loci for Parkinson's disease in Chinese population. | Pan H et al. | — | 2023 | → |
| Genome-wide polygenic risk score, cardiometabolic risk factors, and type 2 diabetes mellitus in the Chinese population. | Huang N et al. | — | 2023 | → |
| Genomic analyses of hair from Ludwig van Beethoven. | Begg TJA et al. | — | 2023 | → |
| Genomic Innovation in Early Life Cardiovascular Disease Prevention and Treatment. | Li C et al. | — | 2023 | → |
| Genomic Investigation of Remission and Relapse of Psychotic Depression Treated with Sertraline plus Olanzapine: The STOP-PD II Study. | Men X et al. | — | 2023 | → |
| Gut microbiome composition may be an indicator of preclinical Alzheimer's disease. | Ferreiro AL et al. | — | 2023 | → |
| GWAS of random glucose in 476,326 individuals provide insights into diabetes pathophysiology, complications and treatment stratification. | Lagou V et al. | — | 2023 | → |
| Hofbauer cell function in the term placenta associates with adult cardiovascular and depressive outcomes. | Fitzgerald E et al. | — | 2023 | → |
| Host Genetic Factors, Comorbidities and the Risk of Severe COVID-19. | Zhu D et al. | — | 2023 | → |
| Identification of 13 Novel Loci in a Genome-Wide Association Study on Taiwanese with Hepatocellular Carcinoma. | Liu TY et al. | — | 2023 | → |
| Identification of loci involved in childhood visual acuity and associations with cognitive skills and educational attainment. | Schmitz J et al. | — | 2023 | → |
| Identification of novel functional brain proteins for treatment-resistant schizophrenia: Based on a proteome-wide association study. | Wei W et al. | — | 2023 | → |
| Identifying genetic variants associated with amphotericin B (AMB) resistance in <i>Aspergillus fumigatus</i> via <i>k-</i>mer<i>-</i>based GWAS. | Chen MM et al. | — | 2023 | → |
| Integration of epigenetic and genetic profiles identifies multiple sclerosis disease-critical cell types and genes. | Ma Q et al. | — | 2023 | → |
| Interaction of genetic liability for attention deficit hyperactivity disorder (ADHD) and perinatal inflammation contributes to ADHD symptoms in children. | Takahashi N et al. | — | 2023 | → |
| Interactions between genetic risk for 21 neurodevelopmental and psychiatric disorders and sport activity on youth mental health. | Misztal MC et al. | — | 2023 | → |
| Investigating genetically stratified subgroups to better understand the etiology of alcohol misuse. | Thijssen AB et al. | — | 2023 | → |
| Investigating the causal relationships between excess adiposity and cardiometabolic health in men and women. | Mutie PM et al. | — | 2023 | → |
| <i>RBFOX1</i> and Working Memory: From Genome to Transcriptome Revealed Posttranscriptional Mechanism Separate From Attention-Deficit/Hyperactivity Disorder. | Zhong Y et al. | — | 2023 | → |
| Late-life onset psychotic symptoms and incident cognitive impairment in people without dementia: Modification by genetic risk for Alzheimer's disease. | Creese B et al. | — | 2023 | → |
| Leveraging Multi-Ancestry Polygenic Risk Scores for Body Mass Index to Predict Antiretroviral Therapy-Induced Weight Gain. | Keat K et al. | — | 2023 | → |
| Limited evidence of a shared genetic relationship between C-reactive protein levels and cognitive function in older UK adults of European ancestry. | Packer A et al. | — | 2023 | → |
| Link between cognitive polygenic risk scores and clinical progression after a first-psychotic episode. | Segura AG et al. | — | 2023 | → |
| Loneliness during the Covid-19 pandemic in Germany: Impact of social factors and polygenic risk scores on interpersonal differences in loneliness and mental health. | von Werthern NM et al. | — | 2023 | → |
| Long-term effect of styrene and ethylbenzene exposure on fasting plasma glucose: A gene-environment interaction study. | Yu L et al. | — | 2023 | → |
| Lysosomal polygenic risk is associated with the severity of neuropathology in Lewy body disease. | Tunold JA et al. | — | 2023 | → |
| Mapping Normative Trajectories of Cognitive Function and Its Relation to Psychopathology Symptoms and Genetic Risk in Youth. | Kjelkenes R et al. | — | 2023 | → |
| Mapping the genetic architecture of suicide attempt and suicide death using polygenic risk scores for clinically-related psychiatric disorders and traits. | Otsuka I et al. | — | 2023 | → |
| Maternal depression and the polygenic p factor: A family perspective on direct and indirect effects. | Ayorech Z et al. | — | 2023 | → |
| Mediation and longitudinal analysis to interpret the association between clozapine pharmacokinetics, pharmacogenomics, and absolute neutrophil count. | Lock SK et al. | — | 2023 | → |
| Melancholic features and typical neurovegetative symptoms of major depressive disorder show specific polygenic patterns. | Oliva V et al. | — | 2023 | → |
| Modification of TSH-related genetic effects by indicators of socioeconomic position. | Drogge SC et al. | — | 2023 | → |
| mtPGS: Leverage multiple correlated traits for accurate polygenic score construction. | Xu C et al. | — | 2023 | → |
| Narcolepsy risk loci outline role of T cell autoimmunity and infectious triggers in narcolepsy. | Ollila HM et al. | — | 2023 | → |
| Neuroanatomical correlates of genetic risk for obesity in children. | Morys F et al. | — | 2023 | → |
| Neurogenetic mechanisms of risk for ADHD: Examining associations of polygenic scores and brain volumes in a population cohort. | He Q et al. | — | 2023 | → |
| Novel Genetic Variants in TP37, PIK3R1, CALM1, and PLCG2 of the Neurotrophin Signaling Pathway Are Associated with the Progression from Mild Cognitive Impairment to Alzheimer's Disease. | Li H et al. | — | 2023 | → |
| Obstetric complications and genetic risk for schizophrenia: Differential role of antenatal and perinatal events in first episode psychosis. | Valli I et al. | — | 2023 | → |
| Ocular and neural genes jointly regulate the visuospatial working memory in ADHD children. | Zhao Y et al. | — | 2023 | → |
| Overestimated prediction using polygenic prediction derived from summary statistics. | Park DK et al. | — | 2023 | → |
| Pathway-Specific Polygenic Risk Scores Correlate with Clinical Status and Alzheimer's Disease-Related Biomarkers. | Schork NJ et al. | — | 2023 | → |
| Pharmacokinetics and pharmacogenomics of clozapine in an ancestrally diverse sample: a longitudinal analysis and genome-wide association study using UK clinical monitoring data. | Pardiñas AF et al. | — | 2023 | → |
| Phenotype integration improves power and preserves specificity in biobank-based genetic studies of major depressive disorder. | Dahl A et al. | — | 2023 | → |
| PheWAS and cross-disorder analysis reveal genetic architecture, pleiotropic loci and phenotypic correlations across 11 autoimmune disorders. | Topaloudi A et al. | — | 2023 | → |
| Polygenic adaptation leads to a higher reproductive fitness of native Tibetans at high altitude. | He Y et al. | — | 2023 | → |
| Polygenic Contributions to Chronic Overlapping Pain Conditions in a Large Electronic Health Record Sample. | Schirle L et al. | — | 2023 | → |
| Polygenic indices for cognition in healthy aging; the role of brain measures. | Tsapanou A et al. | — | 2023 | → |
| Polygenic Liability to Alzheimer's Disease Is Associated with a Wide Range of Chronic Diseases: A Cohort Study of 312,305 Participants. | Wu BS et al. | — | 2023 | → |
| Polygenic overlap with body-mass index improves prediction of treatment-resistant schizophrenia. | O'Connell KS et al. | — | 2023 | → |
| Polygenic risk for neuroticism is associated with less efficient control in more difficult situations. | Park H et al. | — | 2023 | → |
| Polygenic risk for schizophrenia and the language network: Putative compensatory reorganization in unaffected siblings. | Chen X et al. | — | 2023 | → |
| Polygenic Risk Score and Rare Variant Burden Identified by Targeted Sequencing in a Group of Patients with Pigment Epithelial Detachment in Age-Related Macular Degeneration. | Wąsowska A et al. | — | 2023 | → |
| Polygenic Risk Score for Cardiovascular Diseases in Artificial Intelligence Paradigm: A Review. | Khanna NN et al. | — | 2023 | → |
| Polygenic risk score penetrance & recurrence risk in familial Alzheimer disease. | Qiao M et al. | — | 2023 | → |
| Polygenic risk score prediction of multiple sclerosis in individuals of South Asian ancestry. | Breedon JR et al. | — | 2023 | → |
| Polygenic risk scores and brain structures both contribute to externalizing behavior in childhood - A study in the Adolescent Brain and Cognitive Development (ABCD) cohort. | Teeuw J et al. | — | 2023 | → |
| Polygenic risk scores and kidney traits in the Hispanic/Latino population: The Hispanic Community Health Study/Study of Latinos. | Zhou LY et al. | — | 2023 | → |
| Polygenic risk scores and the need for pharmacotherapy in neonatal abstinence syndrome. | Bibi S et al. | — | 2023 | → |
| Polygenic risk scores enhance prediction of body mass index increase in individuals with a first episode of psychosis. | Muntané G et al. | — | 2023 | → |
| Polygenic Scores and Onset of Major Mood or Psychotic Disorders Among Offspring of Affected Parents. | Zwicker A et al. | — | 2023 | → |
| Polygenic Susceptibility to Hypertension and Blood Pressure Control in Stroke Survivors. | Acosta JN et al. | — | 2023 | → |
| Potential utility of risk stratification for multicancer screening with liquid biopsy tests. | Kim ES et al. | — | 2023 | → |
| Pragmatic Approach to Applying Polygenic Risk Scores to Diverse Populations. | Patel AP et al. | — | 2023 | → |
| Predictive blood biomarkers and brain changes associated with age-related cognitive decline. | Saunders TS et al. | — | 2023 | → |
| Prenatal Vitamin D Levels Influence Growth and Body Composition until 11 Years in Boys. | Sanguesa J et al. | — | 2023 | → |
| Profiling the inflammatory bowel diseases using genetics, serum biomarkers, and smoking information. | Liu R et al. | — | 2023 | → |
| Proteomic analysis of 92 circulating proteins and their effects in cardiometabolic diseases. | Carland C et al. | — | 2023 | → |
| PRSet: Pathway-based polygenic risk score analyses and software. | Choi SW et al. | — | 2023 | → |
| Pruning and thresholding approach for methylation risk scores in multi-ancestry populations. | Chen J et al. | — | 2023 | → |
| Psychological, endocrine and polygenic predictors of emotional well-being during the COVID-19 pandemic in a longitudinal birth cohort. | Nguyen T et al. | — | 2023 | → |
| Psychosis Endophenotypes: A Gene-Set-Specific Polygenic Risk Score Analysis. | Wang B et al. | — | 2023 | → |
| Quality control and analytic best practices for testing genetic models of sex differences in large populations. | Khramtsova EA et al. | — | 2023 | → |
| Rare coding variants as risk modifiers of the 22q11.2 deletion implicate postnatal cortical development in syndromic schizophrenia. | Lin JR et al. | — | 2023 | → |
| Rare copy number variants in males and females with childhood attention-deficit/hyperactivity disorder. | Jung B et al. | — | 2023 | → |
| Relationship Between Retinal Layer Thickness and Genetic Susceptibility to Age-Related Macular Degeneration in Asian Populations. | Cheong KX et al. | — | 2023 | → |
| Research progress and challenges of preimplantation genetic testing for polygenic diseases. | Wu X et al. | — | 2023 | → |
| Robust Bioinformatics Approaches Result in the First Polygenic Risk Score for BMI in Greek Adults. | Kafyra M et al. | — | 2023 | → |
| Schizophrenia Polygenic Risk During Typical Development Reflects Multiscale Cortical Organization. | Kirschner M et al. | — | 2023 | → |
| Sex differences in the polygenic architecture of hearing problems in adults. | De Angelis F et al. | — | 2023 | → |
| Sex-Specific Genetic and Transcriptomic Liability to Neuroticism. | Wendt FR et al. | — | 2023 | → |
| Sick individuals, sick populations revisited: a test of the Rose hypothesis for type 2 diabetes disparities. | Gupta S et al. | — | 2023 | → |
| Significance tests for R<sup>2</sup> of out-of-sample prediction using polygenic scores. | Momin MM et al. | — | 2023 | → |
| Snoring-related polygenic risk and its relationship with lifestyle factors in a Korean population: KoGES study. | Ryu B et al. | — | 2023 | → |
| Stratified genome-wide association analysis of type 2 diabetes reveals subgroups with genetic and environmental heterogeneity. | Christiansen CE et al. | — | 2023 | → |
| Telomere Length Associations With Clinical Diagnosis, Age, and Polygenic Risk Scores for Anxiety Disorder, Depression, and Bipolar Disorder. | Mutz J et al. | — | 2023 | → |
| Testing a Polygenic Risk Score for Morphological Microglial Activation in Alzheimer's Disease and Aging. | Tio ES et al. | — | 2023 | → |
| Testing for pharmacogenomic predictors of ppRNFL thinning in individuals exposed to vigabatrin. | Boothman I et al. | — | 2023 | → |
| The association between screen time and genetic risks for neurodevelopmental disorders in children. | Takahashi N et al. | — | 2023 | → |
| The Big (Genetic) Sort? A Research Note on Migration Patterns and Their Genetic Imprint in the United Kingdom. | Furuya S et al. | — | 2023 | → |
| The Development of Mental Health Difficulties in Young People With and Without Developmental Language Disorder: A Gene-Environment Interplay Study Using Polygenic Scores. | Toseeb U et al. | — | 2023 | → |
| The Genetic Architectures of Functional and Structural Connectivity Properties within Cerebral Resting-State Networks. | Tissink E et al. | — | 2023 | → |
| The genetic contribution to the comorbidity of depression and anxiety: a multi-site electronic health records study of almost 178 000 people. | Coombes BJ et al. | — | 2023 | → |
| The impact of COVID-19 on a college freshman sample reveals genetic and nongenetic forms of susceptibility and resilience to stress. | Turner CA et al. | — | 2023 | → |
| The impact of placental genomic risk for schizophrenia and birth asphyxia on brain development. | Wortinger LA et al. | — | 2023 | → |
| The neural signatures of psychoses in Alzheimer's disease: a neuroimaging genetics approach. | Manca R et al. | — | 2023 | → |
| The polygenic and reactive nature of observed parenting. | Runze J et al. | — | 2023 | → |
| The polygenic basis of relapse after a first episode of schizophrenia. | Segura ÀG et al. | — | 2023 | → |
| The production of within-family inequality: Insights and implications of integrating genetic data. | Fletcher JM et al. | — | 2023 | → |
| Therapeutic outcomes wide association scan of different antipsychotics in patients with schizophrenia: Randomized clinical trials and multi-ancestry validation. | Lu Z et al. | — | 2023 | → |
| Topic modeling identifies novel genetic loci associated with multimorbidities in UK Biobank. | Zhang Y et al. | — | 2023 | → |
| Transcriptomic risk scores for attention deficit/hyperactivity disorder. | Cabana-Domínguez J et al. | — | 2023 | → |
| Trans-ethnic polygenic risk scores for body mass index: An international hundred K+ cohorts consortium study. | Qu HQ et al. | — | 2023 | → |
| Transferability of the PRS estimates for height and BMI obtained from the European ethnic groups to the Western Russian populations. | Albert EA et al. | — | 2023 | → |
| Transfer learning with false negative control improves polygenic risk prediction. | Jeng XJ et al. | — | 2023 | → |
| Treatment resistance NMDA receptor pathway polygenic score is associated with brain glutamate in schizophrenia. | Griffiths K et al. | — | 2023 | → |
| Unraveling the causal genes and transcriptomic determinants of human telomere length. | Chang Y et al. | — | 2023 | → |
| Use of multiple polygenic risk scores for distinguishing schizophrenia-spectrum disorder and affective psychosis categories in a first-episode sample; the EU-GEI study. | Rodriguez V et al. | — | 2023 | → |
| Whole-exome sequencing analyses in a Saudi Ischemic Stroke Cohort reveal association signals, and shows polygenic risk scores are related to Modified Rankin Scale Risk. | Alkhamis FA et al. | — | 2023 | → |
| Widespread genomic influences on phenotype in Dravet syndrome, a 'monogenic' condition. | Martins Custodio H et al. | — | 2023 | → |
| A comprehensive evaluation of polygenic score and genotype imputation performances of human SNP arrays in diverse populations. | Nguyen DT et al. | — | 2022 | → |
| Advancing our understanding of genetic risk factors and potential personalized strategies for pelvic organ prolapse. | Pujol-Gualdo N et al. | — | 2022 | → |
| A Gene-Environment Interaction Study of Polygenic Scores and Maltreatment on Childhood ADHD. | He Q et al. | — | 2022 | → |
| Alzheimer's Disease Polygenic Risk Score Is Not Associated With Cognitive Decline Among Older Adults With Type 2 Diabetes. | Manzali SB et al. | — | 2022 | → |
| A multi-ethnic polygenic risk score is associated with hypertension prevalence and progression throughout adulthood. | Kurniansyah N et al. | — | 2022 | → |
| Antihypertensive Medication Class and the Risk of Dementia and Cognitive Decline in Older Adults: A Secondary Analysis of the Prospective HELIAD Cohort. | Liampas I et al. | — | 2022 | → |
| A pharmacogenomic assessment of psychiatric adverse drug reactions to levetiracetam. | Campbell C et al. | — | 2022 | → |
| A phenotypic spectrum of autism is attributable to the combined effects of rare variants, polygenic risk and sex. | Antaki D et al. | — | 2022 | → |
| A Polygenic Risk Score Based on a Cardioembolic Stroke Multitrait Analysis Improves a Clinical Prediction Model for This Stroke Subtype. | Cárcel-Márquez J et al. | — | 2022 | → |
| A quantile integral linear model to quantify genetic effects on phenotypic variability. | Miao J et al. | — | 2022 | → |
| A Shifting Relationship Between Sex Hormone-Binding Globulin and Total Testosterone Across Puberty in Boys. | Liao Z et al. | — | 2022 | → |
| A Smoothed Version of the Lassosum Penalty for Fitting Integrated Risk Models Using Summary Statistics or Individual-Level Data. | Hahn G et al. | — | 2022 | → |
| Assessing polygenic risk score models for applications in populations with under-represented genomics data: an example of Vietnam. | Pham D et al. | — | 2022 | → |
| Association of Alzheimer's disease polygenic risk scores with amyloid accumulation in cognitively intact older adults. | Luckett ES et al. | — | 2022 | → |
| Association of maternal polygenic risk scores for mental illness with perinatal risk factors for offspring mental illness. | Ratanatharathorn A et al. | — | 2022 | → |
| Association of polygenic risk for schizophrenia with fast sleep spindle density depends on pro-cognitive variants. | Schilling C et al. | — | 2022 | → |
| Association of polygenic risk scores and hair cortisol with mental health trajectories during COVID lockdown. | Ahrens KF et al. | — | 2022 | → |
| Association of Polygenic Risk Scores With Radiographic Progression in Patients With Rheumatoid Arthritis. | Honda S et al. | — | 2022 | → |
| Association of shift work with incident dementia: a community-based cohort study. | Liao H et al. | — | 2022 | → |
| Association of social isolation, loneliness and genetic risk with incidence of dementia: UK Biobank Cohort Study. | Elovainio M et al. | — | 2022 | → |
| Associations between abdominal adipose tissue, reproductive span, and brain characteristics in post-menopausal women. | Schindler LS et al. | — | 2022 | → |
| Associations between brain imaging and polygenic scores of mental health and educational attainment in children aged 9-11. | Fernandez-Cabello S et al. | — | 2022 | → |
| Associations between depression-relevant genetic risk and youth stress exposure: Evidence of gene-environment correlations. | Feurer C et al. | — | 2022 | → |
| Associations between polygenic risk, negative symptoms, and functional connectome topology during a working memory task in early-onset schizophrenia. | Deng M et al. | — | 2022 | → |
| Associations of Genome-Wide Polygenic Risk Score and Risk Factors With Hypertension in a Japanese Population. | Fujii R et al. | — | 2022 | → |
| Associations of risk genes with onset age and plasma biomarkers of Alzheimer's disease: a large case-control study in mainland China. | Jiao B et al. | — | 2022 | → |
| Attachment Style Moderates Polygenic Risk for Incident Posttraumatic Stress in U.S. Military Veterans: A 7-Year, Nationally Representative, Prospective Cohort Study. | Tamman AJF et al. | — | 2022 | → |
| A two-stage genome-wide association study to identify novel genetic loci associated with acute radiotherapy toxicity in nasopharyngeal carcinoma. | Wang Y et al. | — | 2022 | → |
| Barriers to genetic testing in clinical psychiatry and ways to overcome them: from clinicians' attitudes to sociocultural differences between patients across the globe. | Pinzón-Espinosa J et al. | — | 2022 | → |
| Body mass index and childhood symptoms of depression, anxiety, and attention-deficit hyperactivity disorder: A within-family Mendelian randomization study. | Hughes AM et al. | — | 2022 | → |
| Boosting Schizophrenia Genetics by Utilizing Genetic Overlap With Brain Morphology. | van der Meer D et al. | — | 2022 | → |
| Borderline personality disorder and the big five: molecular genetic analyses indicate shared genetic architecture with neuroticism and openness. | Streit F et al. | — | 2022 | → |
| Calculating Polygenic Risk Scores (PRS) in UK Biobank: A Practical Guide for Epidemiologists. | Collister JA et al. | — | 2022 | → |
| Cerebrospinal fluid tau levels are associated with abnormal neuronal plasticity markers in Alzheimer's disease. | Visser PJ et al. | — | 2022 | → |
| Chemokine receptor 4 expression on blood T lymphocytes predicts severity of major depressive disorder. | Freff J et al. | — | 2022 | → |
| Childhood maltreatment mediates the effect of the genetic background on psychosis risk in young adults. | Marchi M et al. | — | 2022 | → |
| Chronic Stress, Genetic Risk, and Obesity in US Hispanic/Latinos: Results From the Hispanic Community Health Study/Study of Latinos. | Isasi CR et al. | — | 2022 | → |
| Common risk variants for epilepsy are enriched in families previously targeted for rare monogenic variant discovery. | Oliver KL et al. | — | 2022 | → |
| Comparing personalized brain-based and genetic risk scores for major depressive disorder in large population samples of adults and adolescents. | Thng G et al. | — | 2022 | → |
| Conduct Problems and Hair Cortisol Concentrations Decrease in School-Aged Children after VIPP-SD: A Randomized Controlled Trial in Two Twin Cohorts. | Runze J et al. | — | 2022 | → |
| Construction and Application of Polygenic Risk Scores in Autoimmune Diseases. | Khunsriraksakul C et al. | — | 2022 | → |
| Contribution of Common Genetic Variants to Risk of Early-Onset Ischemic Stroke. | Jaworek T et al. | — | 2022 | → |
| Dense phenotyping from electronic health records enables machine learning-based prediction of preterm birth. | Abraham A et al. | — | 2022 | → |
| Development of a polygenic risk score to improve detection of peripheral artery disease. | Wang F et al. | — | 2022 | → |
| Disentangling Genetic Risks for Metabolic Syndrome. | van Walree ES et al. | — | 2022 | → |
| Dissecting Polygenic Etiology of Ischemic Stroke in the Era of Precision Medicine. | Li J et al. | — | 2022 | → |
| Dissecting the genetic architecture of suicide attempt and repeated attempts in Korean patients with bipolar disorder using polygenic risk scores. | Lee D et al. | — | 2022 | → |
| Distinct biological ages of organs and systems identified from a multi-omics study. | Nie C et al. | — | 2022 | → |
| Does genetic predisposition modify the effect of lifestyle-related factors on DNA methylation? | Yu C et al. | — | 2022 | → |
| Early manifestations of genetic risk for neurodevelopmental disorders. | Askeland RB et al. | — | 2022 | → |
| Eating disorder symptoms and their associations with anthropometric and psychiatric polygenic scores. | Abdulkadir M et al. | — | 2022 | → |
| EraSOR: a software tool to eliminate inflation caused by sample overlap in polygenic score analyses. | Choi SW et al. | — | 2022 | → |
| Evidence From Imaging Resilience Genetics for a Protective Mechanism Against Schizophrenia in the Ventral Visual Pathway. | Hettwer MD et al. | — | 2022 | → |
| Evidence From Men for Ovary-independent Effects of Genetic Risk Factors for Polycystic Ovary Syndrome. | Zhu J et al. | — | 2022 | → |
| Exploring the causal effect of maternal pregnancy adiposity on offspring adiposity: Mendelian randomisation using polygenic risk scores. | Bond TA et al. | — | 2022 | → |
| ExPRSweb: An online repository with polygenic risk scores for common health-related exposures. | Ma Y et al. | — | 2022 | → |
| Feasibility and application of polygenic score analysis to the morphology of human-induced pluripotent stem cells. | Coleman JRI | — | 2022 | → |
| From Genotype to Phenotype: Polygenic Prediction of Complex Human Traits. | Raben TG et al. | — | 2022 | → |
| Fully exploiting SNP arrays: a systematic review on the tools to extract underlying genomic structure. | Balagué-Dobón L et al. | — | 2022 | → |
| Functional magnetic resonance imaging data for the association between polygenic risk scores for neuroticism and reward-punishment processing. | Park H et al. | — | 2022 | → |
| Gene set enrichment analysis of pathophysiological pathways highlights oxidative stress in psychosis. | Pistis G et al. | — | 2022 | → |
| Genetically predicted telomere length and Alzheimer's disease endophenotypes: a Mendelian randomization study. | Rodríguez-Fernández B et al. | — | 2022 | → |
| Genetic analyses of the electrocardiographic QT interval and its components identify additional loci and pathways. | Young WJ et al. | — | 2022 | → |
| Genetic Analysis of Lung Cancer and the Germline Impact on Somatic Mutation Burden. | Gabriel AAG et al. | — | 2022 | → |
| Genetic and environment effects on structural neuroimaging endophenotype for bipolar disorder: a novel molecular approach. | Hu B et al. | — | 2022 | → |
| Genetic architecture of orbital telorism. | Knol MJ et al. | — | 2022 | → |
| Genetic Association Between Epigenetic Aging-Acceleration and the Progression of Mild Cognitive Impairment to Alzheimer's Disease. | Liu H et al. | — | 2022 | → |
| Genetic assortative mating for schizophrenia and bipolar disorder. | Jefsen OH et al. | — | 2022 | → |
| Genetic basis of job attainment characteristics and the genetic sharing with other SES indices and well-being. | Song Z et al. | — | 2022 | → |
| Genetic Determinants of Survival in Parkinson's Disease in the Asian Population. | Li C et al. | — | 2022 | → |
| Genetic evidence for the most common risk factors for chronic axonal polyneuropathy in the general population. | Taams NE et al. | — | 2022 | → |
| Genetic Evidence Supporting a Causal Role of Depression in Alzheimer's Disease. | Harerimana NV et al. | — | 2022 | → |
| Genetic risk, incident colorectal cancer, and the benefits of adhering to a healthy lifestyle: A prospective study using data from UK Biobank and FinnGen. | Wu E et al. | — | 2022 | → |
| Genetic Risk, Midlife Life's Simple 7, and Incident Dementia in the Atherosclerosis Risk in Communities Study. | Tin A et al. | — | 2022 | → |
| Genetic risk of type 2 diabetes modifies the effects of a lifestyle intervention aimed at the prevention of gestational and postpartum diabetes. | Huvinen E et al. | — | 2022 | → |
| Genetic risk, parental history, and suicide attempts in a diverse sample of US adolescents. | Barzilay R et al. | — | 2022 | → |
| Genetics-informed precision treatment formulation in schizophrenia and bipolar disorder. | Reay WR et al. | — | 2022 | → |
| Genetics in parkinson's disease: From better disease understanding to machine learning based precision medicine. | Aborageh M et al. | — | 2022 | → |
| Genetic stratification of motor and QoL outcomes in Parkinson's disease in the EARLYSTIM study. | Weiss D et al. | — | 2022 | → |
| Genetic trade-offs between complex diseases and longevity. | Hu D et al. | — | 2022 | → |
| Genome-wide analysis identifies impaired axonogenesis in chronic overlapping pain conditions. | Khoury S et al. | — | 2022 | → |
| Genome-wide and phenome-wide analysis of ideal cardiovascular health in the VA Million Veteran Program. | Huang RDL et al. | — | 2022 | → |
| Genome-wide association analyses of physical activity and sedentary behavior provide insights into underlying mechanisms and roles in disease prevention. | Wang Z et al. | — | 2022 | → |
| Genome-wide association of polygenic risk extremes for Alzheimer's disease in the UK Biobank. | Gouveia C et al. | — | 2022 | → |
| Genome-wide association study identifies Sjögren's risk loci with functional implications in immune and glandular cells. | Khatri B et al. | — | 2022 | → |
| Genome-Wide Association Study of Alzheimer's Disease Brain Imaging Biomarkers and Neuropsychological Phenotypes in the European Medical Information Framework for Alzheimer's Disease Multimodal Biomarker Discovery Dataset. | Homann J et al. | — | 2022 | → |
| Genome-wide association study of cerebellar volume provides insights into heritable mechanisms underlying brain development and mental health. | Tissink E et al. | — | 2022 | → |
| Genome-Wide Gene-Set Analysis Approaches in Amyotrophic Lateral Sclerosis. | Vasilopoulou C et al. | — | 2022 | → |
| Genome-wide variants and polygenic risk scores for cognitive impairment following blood or marrow transplantation. | Sharafeldin N et al. | — | 2022 | → |
| GWAS of depression in 4,520 individuals from the Russian population highlights the role of <i>MAGI2</i> (<i>S-SCAM</i>) in the gut-brain axis. | Pinakhina D et al. | — | 2022 | → |
| Higher educational attainment is associated with longer telomeres in midlife: Evidence from sibling comparisons in the UK Biobank. | Amin V et al. | — | 2022 | → |
| Identification of shared loci associated with both Crohn's disease and leprosy in East Asians. | Jung S et al. | — | 2022 | → |
| Identifying the Common Genetic Basis of Antidepressant Response. | Pain O et al. | — | 2022 | → |
| Immune marker levels in severe mental disorders: associations with polygenic risk scores of related mental phenotypes and psoriasis. | Werner MCF et al. | — | 2022 | → |
| Improving lithium dose prediction using population pharmacokinetics and pharmacogenomics: a cohort genome-wide association study in Sweden. | Millischer V et al. | — | 2022 | → |
| Improving polygenic prediction in ancestrally diverse populations. | Ruan Y et al. | — | 2022 | → |
| Improving polygenic risk prediction in admixed populations by explicitly modeling ancestral-specific effects via GAUDI | Sun Q et al. | — | 2022 | — |
| Improving the computation efficiency of polygenic risk score modeling: faster in Julia. | Faucon A et al. | — | 2022 | → |
| Including diverse and admixed populations in genetic epidemiology research. | Caliebe A et al. | — | 2022 | → |
| Influence of gonadal steroids on cortical surface area in infancy. | Alex AM et al. | — | 2022 | → |
| Integrating polygenic risk scores in the prediction of type 2 diabetes risk and subtypes in British Pakistanis and Bangladeshis: A population-based cohort study. | Hodgson S et al. | — | 2022 | → |
| Interaction Testing and Polygenic Risk Scoring to Estimate the Association of Common Genetic Variants With Treatment Resistance in Schizophrenia. | Pardiñas AF et al. | — | 2022 | → |
| Interplay between demographic, clinical and polygenic risk factors for severe COVID-19. | Crossfield SSR et al. | — | 2022 | → |
| Interpretable network-guided epistasis detection. | Duroux D et al. | — | 2022 | → |
| Investigating the Association Between Polygenic Risk Scores for Alzheimer's Disease With Cognitive Performance and Intrinsic Functional Connectivity in Healthy Adults. | Ibnidris A et al. | — | 2022 | → |
| Juvenile idiopathic arthritis polygenic risk scores are associated with cardiovascular phenotypes in early adulthood: a phenome-wide association study. | Clarke SLN et al. | — | 2022 | → |
| Lack of Support for the Genes by Early Environment Interaction Hypothesis in the Pathogenesis of Schizophrenia. | Vassos E et al. | — | 2022 | → |
| Large-scale genome-wide association study of coronary artery disease in genetically diverse populations. | Tcheandjieu C et al. | — | 2022 | → |
| Large uncertainty in individual polygenic risk score estimation impacts PRS-based risk stratification. | Ding Y et al. | — | 2022 | → |
| Latent subtypes of manic and/or irritable episode symptoms in two population-based cohorts - ERRATUM. | Arathimos R et al. | — | 2022 | → |
| Leveraging Large-Scale Genetics of PTSD and Cardiovascular Disease to Demonstrate Robust Shared Risk and Improve Risk Prediction Accuracy. | Seligowski AV et al. | — | 2022 | → |
| Life-Course Associations between Blood Pressure-Related Polygenic Risk Scores and Hypertension in the Bogalusa Heart Study. | Sun X et al. | — | 2022 | → |
| Limb development genes underlie variation in human fingerprint patterns. | Li J et al. | — | 2022 | → |
| Lipidomic risk scores are independent of polygenic risk scores and can predict incidence of diabetes and cardiovascular disease in a large population cohort. | Lauber C et al. | — | 2022 | → |
| Local genetic variation of inflammatory bowel disease in Basque population and its effect in risk prediction. | Garcia-Etxebarria K et al. | — | 2022 | → |
| Longer screen time utilization is associated with the polygenic risk for Attention-deficit/hyperactivity disorder with mediation by brain white matter microstructure. | Yang A et al. | — | 2022 | → |
| Longitudinal relationships of polycyclic aromatic hydrocarbons exposure and genetic susceptibility with blood lipid profiles. | Ma J et al. | — | 2022 | → |
| Long-Lived Individuals Show a Lower Burden of Variants Predisposing to Age-Related Diseases and a Higher Polygenic Longevity Score. | Torres GG et al. | — | 2022 | → |
| Machine learning-based prediction of cognitive outcomes in de novo Parkinson's disease. | Harvey J et al. | — | 2022 | → |
| Mendelian randomization study reveals a causal relationship between adiponectin and LDL cholesterol in Africans. | Meeks KAC et al. | — | 2022 | → |
| Meta-analysis of genome-wide association studies of hoarding symptoms in 27,537 individuals. | Strom NI et al. | — | 2022 | → |
| Meta-analysis of sub-Saharan African studies provides insights into genetic architecture of lipid traits. | Choudhury A et al. | — | 2022 | → |
| Metabolic polygenic risk scores effect on antipsychotic-induced metabolic dysregulation: A longitudinal study in a first episode psychosis cohort. | Segura ÀG et al. | — | 2022 | → |
| Migraine-Associated Common Genetic Variants Confer Greater Risk of Posterior vs. Anterior Circulation Ischemic Stroke☆. | Frid P et al. | — | 2022 | → |
| netCRS: Network-based comorbidity risk score for prediction of myocardial infarction using biobank-scaled PheWAS data. | Nam Y et al. | — | 2022 | → |
| Nomograms of human hippocampal volume shifted by polygenic scores. | Janahi M et al. | — | 2022 | → |
| Non-linear machine learning models incorporating SNPs and PRS improve polygenic prediction in diverse human populations. | Elgart M et al. | — | 2022 | → |
| Polygenic association with severity and long-term outcome in eating disorder cases. | Johansson T et al. | — | 2022 | → |
| Polygenic coronary artery disease association with brain atrophy in the cognitively impaired. | de Silva E et al. | — | 2022 | → |
| Polygenic heterogeneity in antidepressant treatment and placebo response. | Nøhr AK et al. | — | 2022 | → |
| Polygenic risk for prostate cancer: Decreasing relative risk with age but little impact on absolute risk. | Schaid DJ et al. | — | 2022 | → |
| Polygenic risk for schizophrenia as a moderator of associations between childhood trauma and schizotypy. | Tonini E et al. | — | 2022 | → |
| Polygenic risk prediction and SNCA haplotype analysis in a Latino Parkinson's disease cohort. | Loesch DP et al. | — | 2022 | → |
| Polygenic Risk Score Effectively Predicts Depression Onset in Alzheimer's Disease Based on Major Depressive Disorder Risk Variants. | Upadhya S et al. | — | 2022 | → |
| Polygenic risk score for peripheral artery disease: A tool to refine risk stratification. | Kullo IJ | — | 2022 | → |
| Polygenic Risk Score Impact on Susceptibility to Age-Related Macular Degeneration in Polish Patients. | Wąsowska A et al. | — | 2022 | → |
| Polygenic Risk Score in African populations: progress and challenges. | Adam Y et al. | — | 2022 | → |
| Polygenic risk scores for antisocial behavior in relation to amygdala morphology across an attention deficit hyperactivity disorder case-control sample with and without disruptive behavior. | Kleine Deters R et al. | — | 2022 | → |
| Polygenic Risk Scores for Blood Pressure to Assess the Risk of Severe Bevacizumab-Induced Hypertension in Cancer Patients (Alliance). | Quintanilha JCF et al. | — | 2022 | → |
| Polygenic risk scores for neuropsychiatric, inflammatory, and cardio-metabolic traits highlight possible genetic overlap with suicide attempt and treatment-emergent suicidal ideation. | Fanelli G et al. | — | 2022 | → |
| Polygenic risk scores for prediction of breast cancer risk in Asian populations. | Ho WK et al. | — | 2022 | → |
| Polygenic Risk Scores in Alzheimer's Disease Genetics: Methodology, Applications, Inclusion, and Diversity. | Clark K et al. | — | 2022 | → |
| Polygenic risk scores of endo-phenotypes identify the effect of genetic background in congenital heart disease. | Spendlove SJ et al. | — | 2022 | → |
| Polygenic risk score trend and new variants on chromosome 1 are associated with male gout in genome-wide association study. | Chang YS et al. | — | 2022 | → |
| Polygenic scores for empathy associate with posttraumatic stress severity in response to certain traumatic events. | Wendt FR et al. | — | 2022 | → |
| Polygenic Scores in Psychiatry: On the Road From Discovery to Implementation. | Lewis CM et al. | — | 2022 | → |
| Polygenic Scores of Alzheimer's Disease Risk Genes Add Only Modestly to APOE in Explaining Variation in Amyloid PET Burden. | Ramanan VK et al. | — | 2022 | → |
| Predicting Alcohol Use From Genome-Wide Polygenic Scores, Environmental Factors, and Their Interactions in Young Adulthood. | Kandaswamy R et al. | — | 2022 | → |
| Predicting mortality among ischemic stroke patients using pathways-derived polygenic risk scores. | Li J et al. | — | 2022 | → |
| Prediction value of the genetic risk of type 2 diabetes on the amnestic mild cognitive impairment conversion to Alzheimer's disease. | Yang J et al. | — | 2022 | → |
| Quantitative multidimensional phenotypes improve genetic analysis of laterality traits. | Schmitz J et al. | — | 2022 | → |
| Rare copy number variation in posttraumatic stress disorder. | Maihofer AX et al. | — | 2022 | → |
| Real-time individual benefit from social interactions before and during the lockdown: the crucial role of personality, neurobiology and genes. | Monninger M et al. | — | 2022 | → |
| Reconstructing SNP allele and genotype frequencies from GWAS summary statistics. | Yang Z et al. | — | 2022 | → |
| Research Review: A guide to computing and implementing polygenic scores in developmental research. | Allegrini AG et al. | — | 2022 | → |
| Risk factor profiles for depression following childbirth or a chronic disease diagnosis: case-control study. | Jermy BS et al. | — | 2022 | → |
| Role of Polygenic Risk Score in the Familial Transmission of Bipolar Disorder in Youth. | Birmaher B et al. | — | 2022 | → |
| Schooling substantially improves intelligence, but neither lessens nor widens the impacts of socioeconomics and genetics. | Judd N et al. | — | 2022 | → |
| Self-reported walking pace, polygenic risk scores and risk of coronary artery disease in UK biobank. | Zaccardi F et al. | — | 2022 | → |
| Significant sparse polygenic risk scores across 813 traits in UK Biobank. | Tanigawa Y et al. | — | 2022 | → |
| Social and genetic associations with educational performance in a Scandinavian welfare state. | Isungset MA et al. | — | 2022 | → |
| Stratifying the autistic phenotype using electrophysiological indices of social perception. | Mason L et al. | — | 2022 | → |
| Study of the Combined Effect of Maternal Tobacco Smoking and Polygenic Risk Scores on Birth Weight and Body Mass Index in Childhood. | Fuentes-Paez G et al. | — | 2022 | → |
| The genetic architecture of Alzheimer disease risk in the Ohio and Indiana Amish. | Osterman MD et al. | — | 2022 | → |
| The genetic architecture of pneumonia susceptibility implicates mucin biology and a relationship with psychiatric illness. | Reay WR et al. | — | 2022 | → |
| The genetic backbone of ankylosing spondylitis: how knowledge of genetic susceptibility informs our understanding and management of disease. | Kenyon M et al. | — | 2022 | → |
| The impact of digital media on children's intelligence while controlling for genetic differences in cognition and socioeconomic background. | Sauce B et al. | — | 2022 | → |
| The Polygenic Risk Score Knowledge Base offers a centralized online repository for calculating and contextualizing polygenic risk scores. | Page ML et al. | — | 2022 | → |
| The Value of Rare Genetic Variation in the Prediction of Common Obesity in European Ancestry Populations. | Wang Z et al. | — | 2022 | → |
| Transcriptome-wide association study of HIV-1 acquisition identifies <i>HERC1</i> as a susceptibility gene. | Duarte RRR et al. | — | 2022 | → |
| Transcriptomic-based clustering of human atherosclerotic plaques identifies subgroups with different underlying biology and clinical presentation. | Mokry M et al. | — | 2022 | → |
| Transferability of genetic risk scores in African populations. | Kamiza AB et al. | — | 2022 | → |
| Unsuppressed Striatal Activity and Genetic Risk for Schizophrenia Associated With Individual Cognitive Performance Under Social Competition. | Zhang Y et al. | — | 2022 | → |
| Using phenotype risk scores to enhance gene discovery for generalized anxiety disorder and posttraumatic stress disorder. | Wendt FR et al. | — | 2022 | → |
| Using Polygenic Risk Scores Related to Complex Traits to Predict Production Performance in Cross-Breeding of Yeast. | Dai Y et al. | — | 2022 | → |
| Visual masking deficits in schizophrenia: a view into the genetics of the disease through an endophenotype. | Shaqiri A et al. | — | 2022 | → |
| Association of the Polygenic Risk Score With the Probability of Prodromal Parkinson's Disease in Older Adults. | Maraki MI et al. | — | 2021 | → |
| Associations Between High Plasma Methylxanthine Levels, Sleep Disorders and Polygenic Risk Scores of Caffeine Consumption or Sleep Duration in a Swiss Psychiatric Cohort. | Laaboub N et al. | — | 2021 | → |
| Biology of Perseverative Negative Thinking: The Role of Timing and Folate Intake. | Eszlari N et al. | — | 2021 | → |
| Controlling for background genetic effects using polygenic scores improves the power of genome-wide association studies. | Bennett D et al. | — | 2021 | → |
| Discovery of new genetic loci for male sexual orientation in Han population. | Hu SH et al. | — | 2021 | → |
| Drinking and smoking polygenic risk is associated with childhood and early-adulthood psychiatric and behavioral traits independently of substance use and psychiatric genetic risk. | De Angelis F et al. | — | 2021 | → |
| GWAS of stool frequency provides insights into gastrointestinal motility and irritable bowel syndrome. | Bonfiglio F et al. | — | 2021 | → |
| Identification of Three Novel Susceptibility Loci for Inflammatory Bowel Disease in Koreans in an Extended Genome-Wide Association Study. | Jung S et al. | — | 2021 | → |
| Incorporating functional priors improves polygenic prediction accuracy in UK Biobank and 23andMe data sets. | Márquez-Luna C et al. | — | 2021 | → |
| Influence of polygenic risk scores for schizophrenia and resilience on the cognition of individuals at-risk for psychosis. | He Q et al. | — | 2021 | → |
| Interplay between Genome, Metabolome and Microbiome in Colorectal Cancer. | Garcia-Etxebarria K et al. | — | 2021 | → |
| <i>STXBP6</i> and <i>B3GNT6</i> Genes are Associated With Selective IgA Deficiency. | Lim CK et al. | — | 2021 | → |
| Pleiotropy between language impairment and broader behavioral disorders-an investigation of both common and rare genetic variants. | Nudel R et al. | — | 2021 | → |
| Polygenic risk score for bipolar disorder associates with divergent thinking and brain structures in the prefrontal cortex. | Takeuchi H et al. | — | 2021 | → |
| Polygenic Risk Scores Contribute to Personalized Medicine of Parkinson's Disease. | Dehestani M et al. | — | 2021 | → |
| Potential Genetic Overlap Between Insomnia and Sleep Symptoms in Major Depressive Disorder: A Polygenic Risk Score Analysis. | Melhuish Beaupre LM et al. | — | 2021 | → |
| Sleep Polygenic Risk Score Is Associated with Cognitive Changes over Time. | Tsapanou A et al. | — | 2021 | → |
| Statistical models and computational tools for predicting complex traits and diseases. | Chung W | — | 2021 | → |
| Systematic investigation of a potential epidemiological and genetic association between male androgenetic alopecia and COVID-19. | Henne SK et al. | — | 2021 | → |
| Vitamin D and the risk of treatment-resistant and atypical depression: A Mendelian randomization study. | Arathimos R et al. | — | 2021 | → |