Chunk #18 — Benchmarking

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PRSice-2: Polygenic Risk Score software for biobank-scale data.

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While PRSs generated by PRSice-2 do not seem to fully optimize predictive accuracy, the simple approach and typically fewer SNPs exploited allow for easier interpretation of the results compared with methods that use all SNPs [27]. Moreover, the efficiency and predictive power of PRSice-2 make it an ideal tool to perform PRS analyses at scale.