We have introduced PRSice-2, a software program for the automation of PRS analyses applied to large-scale genotype-phenotype data. Our results demonstrate that PRSice-2 is the most efficient among leading PRS software, outperforming lassosum [15] and LDpred [16]. As data sizes increase and more sophisticated PRS analyses, such as multi-trait or gene set–based PRS analyses, become common, the efficiency advantages of PRSice-2 will become increasingly important.
