PRSice-2 uses the same standard approach to PRS calculation as PRSice, involving clumping single-nucleotide polymorphisms (SNPs) (thinning SNPs according to linkage disequilibrium and P-value) and then performing P-value thresholding, known as the “C+T” method [14], and retains the majority of the features of its predecessor [13], including automatic strand flipping, clumping [18], and calculation and evaluation of PRS under few (“fastscore”) or many (“high-resolution scoring”) P-value thresholds.
