Briefly, the main features of PRSice-2 are: Handles large-scale PRS analyses of both genotyped and imputed dataComputes empirical association P-values to account for overfittingCan perform PRS analyses on a large number of target phenotypes simultaneouslyProvides several options for imputing missing genotypesAllows calculation of PRS based on different inheritance models, including additive, dominant, recessive, and heterozygous modelsAutomatically generates dummy variables for categorical covariatesCan perform regression to estimate relative effect/risk corresponding to samples in user-defined stratum of the population. Can output quantile and strata plotsAmenable to user extensions, such as relating to input data format, regression modelling, and output
