These results exemplify the potential gain in predictive power when using dosage data compared to using genotyped or best-guess genotype data. However, given the modest increases in predictive power, users may wish to perform first-pass analyses on genotyped-only data before application to the more computationally intensive imputed data. A further challenge in exploiting imputed data is that there are numerous imputed formats in use in the field. While it is difficult to support all imputed formats, PRSice-2 adopts a modular approach, which allows simple incorporation of supports for additional data formats (e.g., VCF) in the future.
