To facilitate biological interpretation and laboratory follow up, we sought to prioritise specific variants and genes most likely to explain associations using a combination of fine-mapping, transcriptomic analysis, and functional genomic annotations. The initial steps in these procedures were necessarily based on 293 index SNPs (255 loci) that attained significance in the core PGC dataset (Methods, Supplementary Table 10), we then focussed on the loci that remained significant in the full Extended GWAS to maximise robustness (Figure 1).
