Handling altered cannabinoid receptor binding densities at caudal levels of the caudate putamen (Interaction effect: F1,23 = 8.59, P = 0.008; η2 = 0.189; Fig. 8a), specifically in the dorsal caudate putamen (Interaction effect: F1,23 = 4.80, P = 0.039; η2 = 0.126; Data not shown), and anterior thalamus (Interaction effect: F1,23 = 7.15, P = 0.014; η2 = 0.177; Fig. 8b) in a manner that was dependent on rearing conditions. Handling increased cannabinoid receptor densities in these regions in group- (P < 0.05), but not isolation-reared rats (P > 0.05 for all comparisons; Fig. 8a–b). No changes in cannabinoid receptor densities were found in any other structure examined (P > 0.05; see Table 1).
