Similarly, Genopedia provides a gene-centered summary view of genetic association studies. The system translates a gene name, gene symbol, gene alias or protein name entered by the user into a HUGO gene symbol. Genopedia displays information about diseases that have been studied in association with a given gene using a format similar to that described for Phenopedia (Supplementary Fig. 2A). A gene–disease network is also generated by defining two genes as ‘connected’ if they have been studied for association with the same disease(s) (Goh et al., 2007). The list of connected genes is displayed along with the disease(s) that connect them (Supplementary Fig. 2B). Each search result page provides links to the foremost gene-centered databases, including NCBI Entrez Gene (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=gene), GeneCards (http://www.genecards.org/), PharmGKB (http://www.pharmgkb.org/) and ALFRED (http://alfred.med.yale.edu/). Genopedia has also become a major resource linkout for these major gene-centered databases.
