We applied the method developed by Goh et al. (2007) to build a literature-based disease–gene network in which two diseases are ‘connected’ if they have been studied for association with the same gene(s). For a given disease, the display page lists each connected disease and the genes studied for association with both diseases (Supplementary Fig. 1B); data are shown in tabular form, without graphic representation. In addition, genes in the tables can be grouped according to pathways defined in KEGG (Supplementary Fig. 1C). The summary page provides links to some major disease-specific databases and published field synopses (Khoury et al., 2009) if available.
