Unlike the UW-TTURC trial results, rs16969968 genotype was not associated with abstinence in the placebo group or the varenicline group (Table 1; Figure 1), and there is no pharmacogenetic interaction. Given the sample size (n=403 in placebo; n=428 in varenicline), 2-sided α of 0.05, and baseline abstinence rate of 0.21, we had power to detect a genotypic association with an OR of 0.66 or lower. In the varenicline trial, NNT for varenicline did not vary much by genotype (NNT=3.6, 3.3, 2.9 for smokers with AA, GA GG genotypes, respectively).
