To link identified risk variants to genes, we used the set of credible variants (identified as described above) for each locus and linked variants to genes based on genomic position and functional annotations in FUMA23. Protein coding genes were mapped if they were located with a distance of 10 kb upstream or downstream of the index variants or if a credible variant was annotated to the gene based on eQTL data or chromatin interaction data from human brain (datasets used are listed in the Supplementary Note). The mapping linked credible variants to 76 ADHD prioritized risk genes. These genes were used in gene-set enrichment analyses to evaluate if the candidate genes were enriched among (1) genes differentially expressed in specific brain tissues, (2) genes differentially expressed at specific brain developmental stages, (3) genes encoding proteins involved in synapses and (4) genes encoding proteins in specific biological pathways. We corrected for multiple testing separately for each of these hypotheses. The first two aims were addressed by performing enrichment analyses in the GENE2FUNC module in FUMA. Enrichment of ADHD risk genes among
