genes encoding proteins in specific biological pathways. We corrected for multiple testing separately for each of these hypotheses. The first two aims were addressed by performing enrichment analyses in the GENE2FUNC module in FUMA. Enrichment of ADHD risk genes among predefined sets of differentially expressed genes in GTEx (54 tissue types) and BrainSpan (29 different ages of samples and 11 general developmental stages) data using hypergeometric test, and protein-coding genes were chosen as background genes.