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Chunk #68 — Methods — Functional mapping and annotation

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International meta-analysis of PTSD genome-wide association studies identifies sex- and ancestry-specific genetic risk loci.
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v7 brain tissue, RNA-seq data from the CommonMind Consortium and the BRAINEAC database. Chromatin interaction mapping was performed using built-in chromatin interaction data from the dorsolateral prefrontal cortex, hippocampus and neuronal progenitor cell line. We used a FDR q < 1 × 10−5 to define significant interactions, based on previous recommendations, modified to account for the differences in cell lines used here. SNPs were also checked for previously reported phenotypic associations in published GWAS listed in the NHGRI-EBI catalog.