For some of the CHRN genes highlighted here, other SNPs have been reported in independent studies of smoking or nicotine dependence. In CHRNB1, different SNPs have been reported (Lou et al., 2006, Philibert et al., 2009). Lou et al. did not genotype rs7210231, but reported rs2302763 as associated with smoking quantity in EAs; we genotyped the r2 proxy rs3855924 (r2 = 1 with rs2302763 in HapMap CEU) and did not find association with nicotine dependence in our sample. Philibert et al. did not report on rs7210231 but in their predominantly European-descent sample found evidence for rs3855924 and rs4796418, which are not associated in our samples. Our findings appear to highlight a different region in this gene. In CHRNA7, rs1909884 (Greenbaum et al., 2006) and rs904952, rs10438287 and rs12915265 (Philibert et al., 2009) have been reported; the latter two were tested in our sample but other SNPs are more strongly associated. For rs1909884 our closest proxy is rs904951 (r2 = 0.51 in CEU but only 0.26 in YRI) which is highlighted in Table 2 and nominally associated in AAs. Rs904952 is
