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Chunk #39 — DISCUSSION AND CONCLUSIONS

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Multiple cholinergic nicotinic receptor genes affect nicotine dependence risk in African and European Americans.
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in our sample but other SNPs are more strongly associated. For rs1909884 our closest proxy is rs904951 (r2 = 0.51 in CEU but only 0.26 in YRI) which is highlighted in Table 2 and nominally associated in AAs. Rs904952 is completely correlated with rs904951 in both CEU and YRI (r2 = 1.0). Thus our evidence for rs904951 supports the report in (Philibert et al., 2009) and extends the finding by showing association of rs904951 and other CHRNA7 SNPs in a sizeable African-American sample.