Since September 2008, we have updated the genome assemblies for horse, human, opossum, medaka and yeast. The new human assembly, UCSC version hg19 (Genome Reference Consortium GRCh37), includes pairwise alignments to 4 primates, 7 non-primate placental mammals and 12 non-placental vertebrates, and we plan to add a 46-species Conservation track by early 2010. We expect the set of hg19 annotations to grow substantially during the next year as new tracks are added and ENCODE datasets are migrated from the hg18 human assembly.