decrease in stimulation and liking, with sustained wanting that may underlie desire for further drinking to offset reduction of hedonic effects. Although acute responses to the high alcohol dose producing peak BrACs of 0.08% to 0.09% were more informative than responses to the lower dose, future studies of higher alcohol doses or sustained drinking for a longer interval may help discern whether positive effects decrease (ie, acute tolerance), remain elevated, or increase over time. Such studies would offer an ecologically valid model of more extreme binge episodes. Indeed, among the highly frequent and exacerbating HD binge drinkers, maximal drinking amounts were from 11 to 14 drinks on an occasion (Table 3), resulting in BrACs that would likely be 2 to 3 times the legal limit for driving.
