The resting state default mode network describes a network of connected brain areas that are particularly active when an individual is not performing a task and is comprised of the ventral medial prefrontal cortex, cingulate/retrosplenial cortex, inferior parietal lobule, lateral temporal cortex, dorsal medial prefrontal cortex, and hippocampal formation (Buckner, Andrews-Hanna, & Schacter, 2008). AUD changes the resting state default-mode network from connectivity between posterior cingulate cortex and middle cingulate cortex (MCC) towards increased connectivity between midbrain and MCC. This reflects a shift from higher order structures to more cue-reactive circuits, indicating compromised executive control (Muller-Oehring, Jung, Pfefferbaum, Sullivan, & Schulte, 2015; Schulte, Muller-Oehring, Sullivan, & Pfefferbaum, 2012). Alcoholics relative to healthy controls have higher regional homogeneity (ReHo) values during resting state. ReHo describes the functional connectivity between a given activation cluster and its nearest neighboring activation cluster and thus can be understood as an index of network centrality (for a detailed technical review see, for a detailed technical review see, Jiang & Zuo, 2016). Hence the changes in ReHo of AUD individuals indicate that specific regional neuropopulations are more
