Three SNPs, rs494270 (intergenic) and the GABRA2 tag SNPs rs279863 and rs279858, were located within the GABRA2 haplotype block 2 that has been associated with AUD in previous studies (Table 1). SNPs rs279863 and rs279858, which are in allelic identity, showed a significant genotypic association with AUD due to the fact that alcoholics had an excess of both homozygotes: 11 (0.44 vs 0.34) and 22 (0.18 vs 0.16), and a corresponding deficit of heterozygotes (0.38 vs 0.50) compared with non-alcoholics, respectively. There were no significant differences in allele frequencies.
