Chunk #8 — Do cannabinoids cause short-lived positive psychotic symptoms, negative symptoms and cognitive deficits in the general population? — The effects of medicinal cannabinoids
Another source of data on the association between cannabis and psychosis comes from the known effects of synthetic cannabinoids, such as Δ9-THC, nabilone, and levonantradol, which have been used in the treatment of chemotherapy-induced nausea, spasticity from multiple sclerosis, and pain syndromes. The reported effects of these drugs include anxiety and panic, fear and paranoia, amnesia, “loss of control”, thought disturbances, feelings of unreality, apprehension, dissociation, depersonalization, dysphoria, difficulty concentrating, hallucinations, and other perceptual alterations (Marinol Product Monograph) [36, 88, 106, 122, 136, 219]. The incidence of these effects has been reported to increase both with increasing dose and with repeated dosing [36, 206]. Finally, in some clinical trials, some subjects refused further testing because they experienced disturbing psychotropic effects.
