We further examined whether high-ranking drug targets were enriched for 159 drug classes defined by Anatomical Therapeutic Chemical (ATC) codes. We identified two broad classes where drugs were significantly enriched for association in drug target analyses (Supplementary Table 29). These were opioid drugs (ATC code N02A, P = 2.75 × 10−4), and psycholeptics (ATC code N05, P = 3.62 × 10−5), particularly antipsychotics (ATC code N05A, P = 3.55 × 10−7). However, sensitivity analyses limited to drugs with 10 or more targets identified no significant drug target sets nor drug classes.
