Chunk #27 — Results — Drug target and class analysis

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Genome-wide association analyses identify 95 risk loci and provide insights into the neurobiology of post-traumatic stress disorder.

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We extended MAGMA gene-set analysis to investigate 1,530 gene sets comprising known drug targets (Supplementary Table 28). We identified one drug (stanozolol, an anabolic steroid) significantly enriched for targets associated with PTSD (P = 1.62 × 10−5). However, stanozolol has only two target genes in our analyses (ESR1, JUN), and likely reflects the strong association of ESR1 with PTSD in gene-level analyses (P = 8.94 × 10−12).