Considering all 1,114 traits with SNP-based heritability z > 6 available from the Pan-UKB54 analysis, we observed Bonferroni-significant rg of PTSD with 73% of them (Supplementary Table 27). Examining the extremes of estimates observed, the top positive rg was with sertraline prescription (rg = 0.88, P = 3.25 × 10−20), a medication frequently prescribed for PTSD and other internalizing disorders55. Other leading associations included medication poisonings (e.g. “Poisoning by psychotropic agents” rg = 0.88, P = 3.92 × 10−20), which could support a link with accidental poisonings or self-harm behaviors56,57. Converging with epidemiologic studies, there were correlations with gastrointestinal symptoms58 (e.g., “Nausea and vomiting” rg = 0.80, P = 2.39 × 10−16), mental health comorbidities59 (e.g., “Probable Recurrent major depression (severe)” rg = 0.87, P = 1.18 × 10−18; “Recent restlessness” rg = 0.86, P = 4.21 × 10−54), chronic pain60 (multi-site chronic pain rg = 0.63, P = 7.5 × 10−301) and reduced longevity61–63 (“Mother’s age at death” rg = −0.51, P = 7.6 × 10−27).
