Of the 2 SNPs that were genotyped in EA cases, only rs62638690 was significantly associated with drug addiction. The minor allele frequency in cases was 0.38% compared to 0.79% in the control population (p=0.02, OR= 0.47[0.24–0.92]), suggesting a protective effect against drug addiction. This association did withstand correction for multiple testing (Bonferroni correction = 0.04). rs17174794 was not found to be significantly associated with drug addiction in EA’s (Table 1). The total rare variant burden in cases compared to control in the EA population was not found to be statistically different (p=0.796, χ2=0.07, OR=0.94[0.64–1.36]).
