Interestingly, the results demonstrated that the physical interaction between Homer 1 b/c and dynamin-3 was reduced with increasing age, but this observation was most pronounced in control subjects (r=−0.859, p=0.003; heroin subjects, r=−0.394, p=0.06). A significant correlation was also observed in relation to dynamin-3 levels and age in controls (not heroin subjects) (r=0.762, p=0.028), but it was a positive relationship to age. There was no correlation to age in regard to Homer 1b/c levels in the lateral amygdala. Of the other glutamateric proteins studied, only GluA1 levels were significantly correlated to age, and this was only apparent in control subjects (r=−0.578, p < 0.05).
