To handle the increasing usage of the DGIdb, the database backend has undergone significant updates. One of the most notable is the upgrade from Rails 3 to the Rails 5 framework. We also added 22 new tables to the PostgreSQL database schema consisting of 2 326 676 records supporting the described changes and added 4065 new lines of code to the repository, an expansion of the codebase by 18.9%. This activity can be seen through the commit history to the GitHub repository in Supplementary Figure S5. For access to this code and data, please see the availability section below.