We have adopted two strategies in reporting the findings from this study. In the first, we performed GC-correction of data from DGI, FUSION and WTCCC prior to stage 1 meta-analysis. We corrected each individual study for the GC inflation observed (directly genotyped and imputed data separately), and combined results across studies. We present the genome-wide distribution of association statistics in Supplementary Figure 1. We note that, after study-specific genomic control adjustment, the estimated inflation factor for the stage-1 meta-analysis test statistic was 1.04.
