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Chunk #17 — Methods — Genomic control (expanded in Supplementary Methods)

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Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes.
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In the second, we combined GC-uncorrected data from DGI, FUSION and WTCCC for stage 1 meta-analysis and did not correct the meta-analysis test statistics for the overall GC (to guard against over-conservativeness in the estimate of strength of association for interesting signals). We also present the genome-wide distribution of these statistics in Supplementary Figure 1.